大剂量盐酸氨溴索联合支气管镜治疗老年重症肺炎的效果及对氧供、氧耗的影响  

Effect of high dose ambroxol hydrochloride combined with bronchoscopic treatment in elderly patients with severe pneumonia and influence for oxygen supply and oxygen consumption

作　　者：毛坡 苏祖雄 李炳文 李江平[1] 林进师 程江海 黄国亮 MAO Po;SU Zuxiong;LI Bingwen;LI Jiangping;LIN Jinshi;CHENG Jianghai;HUANG Guoliang(Emergency Center of Anxi County Hospital,Anxi County,Fujian Province,362400,China;Health Company,Service Support Battalion,PLA Unit 73146,Quanzhou City,Fujian Province,362000,China)

机构地区：[1]福建省安溪县医院急诊中心,福建安溪362400 [2]解放军73146部队勤务保障营卫生连,福建泉州362000

出　　处：《蛇志》2024年第3期357-361,共5页Journal of Snake

摘　　要：目的探讨大剂量盐酸氨溴索联合支气管镜治疗老年重症肺炎的疗效及对氧供、氧耗的影响。方法将2022年1月至2023年12月在我院治疗的80例老年重症肺炎患者按随机数字表法分为两组,每组40例。对照组采用常规剂量盐酸氨溴索治疗,观察组采用大剂量盐酸氨溴索联合支气管镜治疗,比较两组患者的治疗效果(总有效率)、治疗前后的重症感染标志物[C-反应蛋白(CRP)、白细胞介素-6(IL-6)及白细胞介素-17(IL-17)]、氧供指标[氧输送量(DO_(2))、氧输送指数(DO_(2)I)]及氧耗指标[氧耗量(VO_(2))、氧耗指数(VO_(2)I)]。结果观察组的总有效率显著优于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者的重症感染标志物、氧供指标及氧耗指标比较,差异均无统计学意义(P>0.05);观察组治疗后第3、7天时的重症感染标志物水平显著低于对照组,治疗后第1、3、7天时的氧供指标及氧耗指标水平均显著高于对照组,差异均有统计学意义(均P<0.05)。结论大剂量盐酸氨溴索联合支气管镜治疗老年重症肺炎的效果显著,可显著改善患者的氧供及氧耗状态,用于治疗老年重症肺炎的价值高。Objective To investigate the effect of high dose ambroxol hydrochloride combined with bronchoscopic treatment in the elderly patients with severe pneumonia and influence for oxygen supply and oxygen consumption.Methods 80 elderly patients with severe pneumonia from January 2022 to December 2023 were divided into two groups with 40 cases in each group by the random number table.The control group were treated with conventional dose ambroxol hydrochloride,the observation group were treated with high dose ambroxol hydrochloride combined with bronchoscopic treatment.Then the therapeutic effect(total effective rates),severe infection markers(CRP,IL-6 and IL-17),oxygen supply indexes(DO_(2)and DO_(2)I)and oxygen consumption indexes(VO_(2)and VO_(2)I)before and after the treatment of two groups were compared.Results The therapeutic effect(total effective rate)of observation group was significantly better than that of control group,the difference was statistically significant(P<0.05).The severe infection markers,oxygen supply indexes and oxygen consumption indexes of two groups before the treatment were compared,the differences were not statistically significant(all P>0.05).The severe infection markers of observation group at third and seventh day after the treatment were significantly lower than those of control group,the oxygen supply indexes and oxygen consumption indexes of observation group at first,third and seventh day after the treatment were significantly higher than those of control group,the differences were all statistically significant(all P<0.05).Conclusion The high dose ambroxol hydrochloride combined with bronchoscopic treatment in the elderly patients with severe pneumonia is relatively better,and it can more effectively improve the oxygen supply and oxygen consumption state of patients,so its application value in the ederly patients with severe pneumonia is relatively higher.

关 键 词：大剂量 常规剂量 盐酸氨溴索 支气管镜 老年重症肺炎 氧供 氧耗 

分 类 号：R563.1[医药卫生—呼吸系统]