血管周围间隙扩散张量成像指数在评估儿童良性Rolandic癫痫脑类淋巴系统功能及疾病状态的价值  

Evaluation of glymphatic system activity and disease state by diffusion tensor image analysis along the perivascular space index in children with benign Rolandic epilepsy

作　　者：高璐 张钠 王小玗 冯钰莹 李贤军[1] 卞益同 刘哲[1] 杨健[1] GAO Lu;ZHANG Na;WANG Xiaoyu;FENG Yuying;LI Xianjun;BIAN Yitong;LIU Zhe;YANG Jian(Department of Radiology,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院医学影像科,西安710061

出　　处：《磁共振成像》2024年第9期6-10,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:81971581、81771810、82272618);陕西省自然基础研究计划项目(编号:2022JQ-811)。

摘　　要：目的探讨血管周围间隙扩散张量成像指数(diffusion tensor image analysis along the perivascular space index,DTI-ALPS index)在评价儿童良性Rolandic癫痫(Rolandic epilepsy,RE)患儿脑类淋巴系统(glymphatic system,GS)功能及疾病状态中的价值。材料与方法选取20例6~12岁的RE患儿(患儿组)与20例年龄、性别匹配的儿童(对照组)行常规MRI及MR扩散张量成像(diffusion tensor imaging,DTI)检查。定量分析两组的DTI-ALPS index。采用Pearson相关分析患儿组DTI-ALPS index与癫痫发作持续时间、发作频率及认知功能的相关性。结果患儿组DTI-ALPS index较对照组降低(患儿组:1.41±0.20,对照组:1.56±0.16;t=-2.620,P=0.013)。两组DTI-ALPS index均与年龄呈正相关(患儿组r=0.483,P=0.002;对照组r=0.534,P<0.001)。患儿组DTI-ALPS index与癫痫发作持续时间、发作频率呈负相关(发作持续时间r=-0.743,P<0.001;发作频率r=-0.460,P=0.044);与总智商(full intelligence quotient,FIQ)及言语智商(verbal intelligence quotient,VIQ)呈正相关(r_FIQ=0.523,P=0.014;r_VIQ=0.563,P=0.001),与操作智商(practical intelligence quotient,PIQ)无相关性。结论DTI-ALPS index可用于评估RE患儿GS功能受损情况,在探究疾病状态中具有较高的价值。Objective:To investigate the value of diffusion tensor image analysis along the perivascular space index(DTI-ALPS index)on glymphatic system(GS)activity and disease state in children with benign Rolandic epilepsy(RE).Materials and Methods:Twenty patients aged 6-12 years with RE and 20 children matched in gender and age underwent conventional MRI and diffusion tensor imaging(DTI).Quantitative analysis DTI-ALPS index between two groups.Meanwhile,correlation of DTI-ALPS index with seizure duration,epileptic frequency and cognitive development were respectively explored via Pearson's coefficient(r).Results:Compared with control group,DTI-ALPS index was higher in control group than patient group(RE:1.41±0.20,Control:1.56±0.16;t=-2.620,P=0.013).DTI-ALPS index positively correlated with age(r_patient=0.483,P=0.002;r_control=0.534,P<0.001),full intelligence quotient(FIQ)and verbal intelligence quotient(VIQ)(r_FIQ=0.523,P=0.014;r_VIQ=0.563,P=0.001).However,DTI-ALPS index gradually decreased with seizure duration and epileptic frequency(r_seizure duration=-0.743,P<0.001;r_epileptic frequency=-0.460,P=0.044).There was no significant associations between DTI-ALPS index and practical intelligence quotient(PIQ).Conclusions:DTI-ALPS index can be used to evaluated impairment of the GS in RE,which has a good prospect for exploring the state of RE.

关 键 词：良性Rolandic癫痫 类淋巴系统 磁共振成像 扩散张量成像 血管周围间隙 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742.1[医药卫生—诊断学]