7T磁共振成像在脑小血管病中的应用进展  

Advancements in the application of 7 T-MRI in cerebral small vessel disease

作　　者：黄沛钰[1,2] 刘晨 甄志铭 张睿婷 HUANG Peiyu;LIU Chen;ZHEN Zhiming;ZHANG Ruiting(Department of Radiology,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China;T Magnetic Resonance Translational Medicine Research Center,Department of Radiology,Southwest Hospital,Army Medical University(Third Military Medical University),Chongqing 400038,China)

机构地区：[1]浙江大学医学院附属第二医院放射科,杭州310009 [2]陆军军医大学第一附属医院放射科7 T磁共振转化医学研究中心,重庆400038

出　　处：《磁共振成像》2024年第9期151-156,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:82371907、82101987)。

摘　　要：脑小血管病在老年人群具有很高的发病率,可显著增加脑卒中和痴呆的发生风险。迄今为止,该疾病尚无有效的临床和体液生物标志物,诊断鉴别高度依赖于MRI。然而,由于临床影像的空间分辨率所限,脑小血管损害难以直接评价,因此研究者们主要使用一些反映脑实质损害的影像标志物来评估小血管损伤。近年来,随着超高场(7T)MRI技术的不断成熟,其在脑小血管病领域的研究亦日趋广泛。7T-MRI能够直接评估脑小血管结构、功能,并显著提高微小脑实质病灶的检测敏感性,为脑小血管病机制研究和精准诊断提供了重要工具。本文将回顾近年来基于7T-MRI的脑小血管病研究,并讨论潜在的问题和未来研究方向,为相关研究工作者提供借鉴。Cerebral small vessel disease has a high incidence rate among the elderly,significantly increasing the risk of stroke and dementia.To date,there are no effective clinical or fluid biomarkers for the disease,and its diagnosis heavily relies on MRI.However,due to the limited spatial resolution of clinical imaging,it's challenging to directly assess small vessel damage.Thus,researchers primarily use imaging biomarkers reflecting cerebral parenchymal damage to evaluate small vessel injury.In recent years,with the continuous maturation of ultra-high-field(7 T)MRI technology,its application in the field of cerebral small vessel disease has become increasingly extensive.7 T-MRI can directly assess the structure and function of small cerebral vessels and significantly enhance the detection sensitivity of minor cerebral parenchymal lesions,providing important tools for the mechanism research and precise diagnosis of cerebral small vessel disease.This article will review the recent research on cerebral small vessel disease based on 7 T-MRI and discuss potential issues and future research directions,offering references for researchers in the field.

关 键 词：脑小血管病 磁共振成像 超高场强 时间飞跃法磁共振血管成像 相位对比磁共振血管成像 磁敏感加权成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743[医药卫生—诊断学]