超早期小骨窗微创术对高血压脑出血VEGF、Ang-1和神经指标的影响  

The Effect of Ultra Early Small Bone Window Minimally Invasive Surgery on VEGF,Ang-1,and Neurological Indicators in Hypertensive Intracere⁃bral Hemorrhage

作　　者：刘相和 宋承明 姜久宁 LIU Xianghe;SONG Chengming;JIANG Jiuning(Department of Neurosurgery,Qihe County People's Hospital,Dezhou 251100,Shandong,China)

机构地区：[1]齐河县人民医院神经外科,山东德州251100

出　　处：《系统医学》2024年第15期14-16,20,共4页Systems Medicine

摘　　要：目的探讨超早期小骨窗微创术治疗高血压脑出血(hypertensive intracerebral hemorrhage,HICH)的疗效以及对患者血管内皮生长因子(vascular endothelial growth factor,VEGF)、血管生成素-1(angiopoietin-1,Ang-1)、神经功能影响。方法非随机选择2022年1月—2023年5月齐河县人民医院收治的90例HICH患者为研究对象,根据发病时间不同分成超早期组(n=45)、早期组(n=45)。两组患者均采取小骨窗微创术治疗,早期组患者在发病6~12 h实施手术,超早期组患者在发病6 h内实施手术。对比两组的治疗效果。结果超早期组治疗总有效率为95.56%(43/45),高于早期组的80.00%(36/45),差异有统计学意义(χ^(2)=5.074,P=0.024)。超早期组术后3 d的VEGF、Ang-1、神经元特异性烯醇化酶水平低于早期组,脑源性神经营养因子水平高于早期组,差异有统计学意义(P均<0.05)。超早期组并发症总发生率低于早期组,差异有统计学意义(P<0.05)。结论应用超早期小骨窗微创术治疗HICH的效果满意,降低血清VEGF、Ang-1水平,改善神经功能指标,术后并发症发生率低。Objective To investigate the treatment of hypertensive intracerebral hemorrhage by ultra-early microinci-sion with small bone window The efficacy of HICH and its effect on the patients with vascular endothelial growth fac-tor(VEGF),angiopoietin-1(Ang-1),and nerve function were reported.Methods 90 patients with HICH admitted to Qihe County People′s Hospital from January 2022 to May 2023 were non-randomly selected as the study subjects,and divided into ultra-early group(n=45)and early group(n=45)according to different onset times.Patients in both groups were treated with small bone window microsurgery,the early group was operated on 6-12 hours after onset,and the ultra-early group was operated on 6 hours after onset.The therapeutic effect of the two groups was com-pared.Results The total effective rate of the super early group was 95.56%(43/45),which was higher than 80.00%(36/45)of the early group,and the difference was statistically significant(χ^(2)=5.074,P=0.024).The levels of VEGF,Ang-1 and neuron-specific enolase in super early group were lower than those in early group 3 days after surgery,and the levels of brain-derived neurotrophic factor were higher than those in early group,and the differeces were sta-tistically significant(all P<0.05).The total complication rate of super early group was lower than that of early group,and the difference was statistically significant(P<0.05).Conclusion The effect of ultra-early small bone window mi-crosurgery in the treatment of HICH is satisfactory,the levels of serum VEGF and Ang-1 are reduced,the neurologi-cal function indexes are improved,and the incidence of postoperative complications is low.

关 键 词：高血压脑出血 超早期小骨窗微创术 疗效 血管内皮生长因子 血管生成素-1 神经功能指标 

分 类 号：R59[医药卫生—内科学]