碳酸氢钠林格液与复方氯化钠注射液治疗脓毒性休克的疗效分析  

Therapeutic Effect of Sodium Bicarbonate Ringer's Solution and Com⁃pound Sodium Chloride Injection on Septic Shock

作　　者：韦方莹 王思媛 于秋雨 WEI Fangying;WANG Siyuan;YU Qiuyu(Department of Critical Care Medicine,Ganyu District People's Hospital,Lianyungang 222100,Jiangsu,China)

机构地区：[1]江苏省连云港市赣榆区人民医院重症医学科,江苏连云港222100

出　　处：《系统医学》2024年第15期70-73,共4页Systems Medicine

摘　　要：目的 探究碳酸氢钠林格液、复方氯化钠注射液应用于脓毒性休克患者中的治疗效果。方法 回顾性选取2021年8月—2023年10月江苏省连云港市赣榆区人民医院接受限制性液体复苏治疗脓毒性休克患者70例的临床资料,按治疗方法分组,对比对照组(n=35,复方氯化钠注射液)与观察组(n=35,碳酸氢钠林格液)在乳酸清除情况、电解质平衡状态上的差异。结果 观察组用药后1、3、6 h乳酸测量值均较对照组低,差异有统计学意义(P均<0.05)。治疗后48 h观察组Cl-水平(106.23±3.17)mmol/L低于对照组(110.94±2.72)mmol/L,差异有统计学意义(t=6.671,P<0.05)。结论 在脓毒性休克的限制性液体复苏治疗之中,推荐选择碳酸氢钠林格液,相比复方氯化钠注射液可有效清除体内乳酸、维持水电解质平衡、预防功能衰竭,促使患者快速康复。Objective To explore the therapeutic effect of sodium bicarbonate Ringer′s and compound sodium chlo-ride injection in the treatment of septic shock.Methods The clinical data of seventy patients with septic shock re-ceived limited fluid resuscitation from August 2021 to October 2023 were retrospectively selected,and divided into two groups according to different treatment methods,the differences of lactate clearance and electrolyte balance be-tween the control group(n=35,compound sodium chloride injection)and the observation group(n=35,sodium bicar-bonate ringer solution)were compared.Results The values of lactic acid in the observation group at 1,3 and 6 hours after treatmentwere significantly lower than those in the control group,the differences were statistically significant(all P<0.05).The level of Cl-was(106.23±3.17)mmol/L after forty-eight hours of treatment,significantly lower than the control group(110.94±2.72)mmol/L,the difference was statistically significant(t=6.671,P<0.05).Conclusion So-dium Bicarbonate Ringer′s solution can be used in the treatment of limited fluid resuscitation in septic shock.Com-pared with compound sodium chloride injection,it can effectively clear lactic acid,maintain water-electrolyte balance and prevent functional failure,promote rapid recovery of patients.

关 键 词：碳酸氢钠林格液 复方氯化钠注射液 脓毒性休克 治疗效果 

分 类 号：R4[医药卫生—临床医学]