静脉用核黄素联合多次间歇蓝光照射治疗新生儿黄疸的临床效果  

Clinical Effect of Intravenous Riboflavin Combined with Intermittent Blue Light Irradiation on Neonatal Jaundice

作　　者：许景秀 沈蓓蓓 XU Jingxiu;SHEN Beibei(Department of Neonatal,Shuyang Hospital Affiliated to Xuzhou Medical University,Shuyang 223600,Jiangsu,China)

机构地区：[1]徐州医科大学附属沭阳医院新生儿科,江苏沭阳223600

出　　处：《系统医学》2024年第15期138-140,144,共4页Systems Medicine

摘　　要：目的 探讨新生儿黄疸患儿间歇蓝光照射治疗配合静脉用核黄素治疗的临床效果。方法 目的抽样法选取2022年1-12月徐州医科大学附属沭阳医院新生儿科收治的120例新生儿黄疸患儿为研究对象,按照不同治疗方式分为对照组和观察组,每组60例。均进行多次间歇蓝光照射疗法治疗,观察组在此基础上联合静脉用核黄素治疗。对比两组临床相关指标、治疗效果、不良反应发生情况。结果 观察组血清胆红素恢复时间、黄疸持续时间、总光疗时间短于对照组,差异有统计学意义(P均<0.05)。观察组治疗总有效率为98.33%(59/60),高于对照组的88.33(53/60),差异有统计学意义(χ^(2)=4.821,P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论 新生儿黄疸在多次间歇蓝光照射治疗的基础上,联合静脉用核黄素可以取得更好的效果。Objective To explore the clinical effect of intermittent blue light irradiation treatment combined with intra-venous riboflavin treatment in children with neonatal jaundice.Methods A total of 120 cases of neonatal jaundice ad-mitted to the Department of Neonatology,Shuyang Hospital Affiliated to Xuzhou Medical University from January to December 2022 were selected as the study objects by target sampling method.They were divided into a control group and an observation group according to different treatment methods,with 60 cases in each group.All patients under-went multiple intermittent blue light irradiation therapies,and the observation group received combined intravenous ri-boflavin therapy on this basis.Compare clinically relevant indicators,treatment efficacy,and incidence of adverse re-actions between two groups.Results The recovery time of serum bilirubin,duration of jaundice,and total phototherapy time in the observation group were shorter than those in the control group,and the differences were statistically signifi-cant(all P<0.05).The total effective rate of the observation group was 98.33%(59/60),which was higher than the con-trol group′s 88.33%(53/60),and the difference was statistically significant(χ^(2)=4.821,P<0.05).The incidence of ad-verse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion In addition to multiple intermittent blue light irradiation treatments,the combination of intravenous riboflavin can achieve better results in neonatal jaundice.

关 键 词：新生儿黄疸 静脉用核黄素 多次间歇蓝光照射 

分 类 号：R722[医药卫生—儿科]