Asiaticoside ameliorates type 2 diabetes mellitus in rats by modulating carbohydrate metabolism and regulating insulin signaling  

作　　者：B.Prathap V.Satyanarayanan K.Duraipandian P.Subashree 

机构地区：[1]Department of Pharmacology,Karpaga Vinayaga Institute of Medical Sciences and Research Center,Maduranthakam 603308,Tamil Nadu,India [2]Department of Pharmacology,SRM Medical College Hospital and Research Center,Kattankulathur 603211,Tamil Nadu,India [3]Department of Anatomy,Karpaga Vinayaga Institute of Medical Sciences and Research Center,Maduranthakam 603308,Tamil Nadu,India [4]Department of Ophthalmology,Karpaga Vinayaga Institute of Medical Sciences and Research Center,Maduranthakam 603308,Tamil Nadu,India

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2024年第9期401-409,共9页亚太热带生物医学杂志（英文版）

摘　　要：Objective:To evaluate the effect of asiaticoside on streptozotocin(STZ)and nicotinamide(NAD)-induced carbohydrate metabolism abnormalities and deregulated insulin signaling pathways in rats.Methods:Asiaticoside(50 and 100 mg/kg body weight)was administered to STZ-NAD-induced diabetic rats for 45 days,and its effects on hyperglycaemic,carbohydrate metabolic,and insulin signaling pathway markers were examined.Results:Asiaticoside increased insulin production,lowered blood glucose levels,and enhanced glycolysis by improving hexokinase activity and suppressing glucose-6-phosphatase and fructose-1,6-bisphosphatase activities.Abnormalities in glycogen metabolism were mitigated by increasing glycogen synthase activity and gluconeogenesis was decreased by decreasing glycogen phosphorylase activity.Furthermore,asiaticoside upregulated the mRNA expressions of IRS-1,IRS-2,and GLUT4 in STZ-NAD-induced diabetic rats and restored the beta cell morphology to normal.Conclusions:Asiaticoside has the potential to ameliorate type 2 diabetes by improving glycolysis,gluconeogenesis,and insulin signaling pathways.

关 键 词：ASIATICOSIDE Type 2 diabetes mellitus Metabolic disorders Carbohydrate metabolism Insulin signaling 

分 类 号：R285.5[医药卫生—中药学]