上感颗粒与连花清瘟颗粒治疗轻症流行性感冒的临床效果比较及对肝肾功能、心肌酶谱的影响  

Comparison of the clinical effects of Shanggan Granules and Lianhua Qingwen Granules in treating mild influenza and the effects on liver and kidney functions and myocardial enzyme profiles

作　　者：郭志洪 刘林洁 李修元 张梦楠 敖素华 GUO Zhihong;LIU Linjie;LI Xiuyuan;ZHANG Mengnan;AO Suhua(Department of Respiratory Medicine,Affiliated Hospital of Traditional Chinese Medicine,Southwest Medical University,Luzhou,Sichuan 646000,China)

机构地区：[1]西南医科大学附属中医医院呼吸内科,四川泸州646000

出　　处：《检验医学与临床》2024年第19期2815-2819,共5页Laboratory Medicine and Clinic

基　　金：国家中医药管理局课题(2019XZZX-LG007)。

摘　　要：目的比较上感颗粒与连花清瘟颗粒治疗轻症流行性感冒的临床效果及对肝肾功能、心肌酶谱的影响。方法选取2021年3-10月西南医科大学附属中医医院门诊或住院收治的确诊的轻症流行性感冒患者95例为研究对象。根据治疗方案的不同,将患者分为对照组(采用连花清瘟胶囊治疗,50例)和试验组(采用上感颗粒治疗,45例),两组均治疗7 d,比较两组中医症候积分、疗效,观察两组患者治疗前后白细胞计数(WBC)、中性粒细胞比例(N%)、C反应蛋白(CRP)、淋巴细胞百分比、血小板计数(PLT)和丙氨酸转氨酶(ALT)、肌酐(Cr)、血尿素氮(BUN),以及心肌酶谱4项[肌酸激酶(CK),肌酸激酶同工酶(CK-MB),乳酸脱氢酶(LDH)和天冬氨酸转氨酶(AST)]的水平变化。结果治疗前、治疗后两组间鼻塞、咽痛、咳痰和头痛症状评分比较,差异均无统计学意义(P>0.05)。治疗后,两组患者鼻塞、咽痛、咳痰和头痛症状评分均低于治疗前,差异均有统计学意义(P<0.01)。治疗后两组症状总积分均低于治疗前症状总积分(P<0.05),但治疗前、治疗后两组间症状总积分及疗效指数比较,差异均无统计学意义(P>0.05)。两组临床疗效比较,差异无统计学意义(Z=0.29,P=0.77)。治疗前、治疗后两组间WBC、N%、淋巴细胞百分比、PLT及ALT、Cr、BUN、CK、CK-MB、LDH、AST水平比较,差异均无统计学意义(P>0.05)。结论上感颗粒和连花清瘟颗粒治疗轻症流行性感冒均安全、有效,能在短时间内改善轻症流行性感冒症状,也不会导致肝功能、肾功能和心肌损伤。Objective To compare the clinical effects of Shanggan Granules and Lianhua Qingwen Granules in treating mild influenza and the effects on liver and kidney functions and myocardial enzyme spectrum.Methods A total of 95 cases of diagnosed mild influenza in the traditional Chinese medicine(TCM)outpatient department or inpatient department from March to October 2021 were selected as the research subjects and divided into the control group(treated with Lianhua Qingwen Granules,50 cases)and experimental group(treated with Shanggan Granules,45 cases)according to different treatment schemes.Both groups were treated for 7 d.The TCM syndrome scores and efficacy were compared between the two groups.The levels change of white blood cell count(WBC),neutrophil proportion(N%),C-reactive protein(CRP),lymphocyte percentage,platelet count(PLT),alanine aminotransferase(ALT),creatinine(Cr),blood urea nitrogen(BUN)as well as 4 items in myocardial enzyme profiles[creatine kinase(CK),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH)and aspartate aminotransferase(AST)]were observed before and after treatment in the two groups.Results There was no statistically significant difference in the scores of nasal congestion,sore throat,expectoration and headache symptom scores before and after treatment between the two groups(P>0.05).After treatment,the symptom scores of nasal congestion,sore throat,expectoration,and headache in both groups were lower than those before treatment,and the differences were statistically significant(P<0.01).After treatment,the total symptom scores in both groups were lower than those before treatment(P<0.05),but there were no statistically significant differences in the total symptom score and efficacy index before and after treatment between the two groups(P>0.05).There was no statistically significant difference in clinical efficacy between the two groups(Z=0.29,P=0.77).There were no statistically significant differences in WBC,N%,percentage of lymphocyte,PLT,ALT,Cr,BUN,CK,CK-MB,LDH,AST levels before an

关 键 词：上感颗粒 轻症流行性感冒 连花清瘟颗粒 疗效 安全性 

分 类 号：R511.7[医药卫生—内科学] R446[医药卫生—临床医学]