桃仁红花煎联合康复训练治疗缺血性脑卒中患者的疗效及对GDF-15、SIRT1和MMP-9水平的影响  

Efficacy of Taoren Honghua Decoction Combined with Rehabilitation Training in the Treatment of Patients with Ischemic Stroke and Its Effects on GDF-15,SIRT1 and MMP-9 Levels

作　　者：李男 朱玉晓 贾建萍 杨培 LI Nan;ZHU Yuxiao;JIA Jianping;YANG Pei(Dept.of Rehabilitation Medicine,Dingzhou People’s Hospital,Hebei Dingzhou 073000,China;Dept.of Acupuncture,Moxibustion and Encephalopathy,Langfang Hospital of Traditional Chinese Medicine,Hebei Langfang 065000,China;Dept.of Radiology,Hebei Xinhe County People’s Hospital,Hebei Xingtai 055650,China)

机构地区：[1]定州市人民医院康复医学科,河北定州073000 [2]廊坊市中医医院针灸脑病科,河北廊坊065000 [3]河北省新河县人民医院神内放射科,河北邢台055650

出　　处：《中国医院用药评价与分析》2024年第9期1050-1053,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：河北省中医药管理局2023年度中医药类科学研究课题计划(No.2023298)。

摘　　要：目的:探讨桃仁红花煎联合康复训练治疗缺血性脑卒中患者的疗效及对血清生长分化因子-15(GDF-15)、沉默信息调节因子1(SIRT1)和基质金属蛋白酶-9(MMP-9)水平的影响。方法:选取2022年2月至2023年7月于定州市人民医院治疗的缺血性脑卒中患者84例,采用随机数字表法分为联合组与训练组,各42例。训练组患者采用基础治疗+康复训练,联合组患者在训练组的基础上加用桃仁红花煎治疗。观察联合组与训练组患者的临床疗效、美国国立卫生院卒中神经功能缺损评分量表(NIHSS)评分、改良Barthel指数(MBI)、血清炎症因子[白细胞介素(IL)1β、IL-6和肿瘤坏死因子α(TNF-α)]、氧化应激相关指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]及血清GDF-15、MMP-9和SIRT1水平。结果:联合组患者的临床总有效率为95.24%(40/42),显著高于训练组的78.57%(33/42),差异有统计学意义(P<0.05)。联合组和训练组患者治疗后的NIHSS评分、IL-1β、IL-6、TNF-α、MDA、GDF-15和MMP-9水平显著降低,MBI评分、SOD和SIRT1水平显著升高,差异均有统计学意义(P<0.05);与训练组比较,联合组患者治疗后的NIHSS评分、IL-1β、IL-6、TNF-α、MDA、GDF-15和MMP-9水平显著降低,MBI评分、SOD和SIRT1水平显著升高,差异均有统计学意义(P<0.05)。结论:桃仁红花煎联合康复训练治疗缺血性脑卒中的临床疗效显著,能有效改善患者的神经功能和脑缺氧缺血再灌注损伤,减轻炎症和应激反应,且显著提高血清SIRT1水平,降低血清GDF-15、MMP-9水平。OBJECTIVE:To probe into the efficacy of Taoren Honghua decoction combined with rehabilitation training in the treatment of patients with ischemic stroke and its effects on growth differentiation factor-15(GDF-15),silent information regulatory factor 1(SIRT1)and matrix metalloproteinase-9(MMP-9)levels.METHODS:A total of 84 patients with ischemic stroke admitted into Dingzhou People’s Hospital our hospital from Feb.2022 to Jul.2023 were extracted to be divided into the combined group and training group through the random number table method,with 42 cases in each group.The training group was given rehabilitation training on the basis of routine treatment,while the combined group was treated with Taoren Honghua decoction on the basis of the training group.The clinical efficacy,National Institutes of Health stroke scale(NIHSS)score,Modified Barthel Index(MBI),serum inflammatory factors[interleukin(IL)1β,IL-6 and tumor necrosis factorα(TNF-α)],oxidative stress related indicators[superoxide dismutase(SOD),malondialdehyde(MDA)],and serum levels of GDF-15,MMP-9 and SIRT1 of two groups were observed.RESULTS:The total clinical effective rate of the combined group was 95.24%(40/42),significantly higher than 78.57%(33/42)of the training group,with statistically significant differences(P<0.05).Compared with before treatment,the NIHSS score,IL-1β,IL-6,TNF-α,MDA,GDF-15 and MMP-9 levels in both groups decreased significantly after treatment,the MBI score,SOD and SIRT1 levels increased significantly,with statistically significant differences(P<0.05).Compared with the training group,the NIHSS score,IL-1β,IL-6,TNF-α,MDA,GDF-15 and MMP-9 levels in the combined group decreased significantly after treatment,the MBI score,SOD and SIRT1 levels increased significantly,with statistically significant differences(P<0.05).CONCLUSIONS:The clinical efficacy of Taoren Honghua decoction combined with rehabilitation training in the treatment of patients with ischemic stroke is significant,which can effectively improve the neurological fun

关 键 词：桃仁红花煎 康复训练 缺血性脑卒中 生长分化因子-15 基质金属蛋白酶-9 沉默信息调节因子1 

分 类 号：R932[医药卫生—生药学]