清热解毒汤治疗哺乳期急性乳腺炎的单臂、前瞻性临床研究  

Clinical Observation on the Treatment of Acute Lactational Mastitis with Qingre Jiedu Decoction:A Single Arm Prospective Study

作　　者：谢晓晨 张董晓[1] 陈雯 黄巧[1] XIE Xiaochen;ZHANG Dongxiao;CHEN Wen;HUANG Qiao(Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京中医医院,北京100010 [2]北京中医药大学,北京100029

出　　处：《中医药学报》2024年第10期62-66,共5页Acta Chinese Medicine and Pharmacology

基　　金：青年岐黄学者项目(国中医药人教函〔2022〕256号);国家中医药管理局中医药古籍文献和特色技术传承专项(GZY-KJS-2022-035);首都临床诊疗技术研究及转化应用(Z211100002921020);中华中医药学会青年求实项目(2023年);北京市属医院科研培育计划(PZ2018022);首都医科大学教育教学改革研究课题(2023JYY326)。

摘　　要：目的:探讨清热解毒汤治疗哺乳期急性乳腺炎的临床疗效。方法:研究共纳入43例哺乳期急性乳腺炎患者,给予清热解毒汤口服,观察患者治疗前后乳腺炎的严重程度指数、体温、乳房疼痛评分、乳房肿块体表面积、乳汁通畅情况、乳头皲裂情况和中医全身症状评分及安全性指标。结果:治疗总有效率为97.67%(42/43),治疗前后乳腺炎的严重程度指数、体温、乳房疼痛评分、乳房肿块体表面积、乳汁通畅情况、乳头皲裂情况、中医全身症状评分差异均有统计学意义(P<0.01)。治疗期间2例哺乳儿出现腹泻,嘱患者停药后症状消失。结论:清热解毒汤治疗哺乳期急性乳腺炎安全有效,值得临床推广应用。Objective:To explore the clinical efficacy of Qingre Jiedu decoction(QJD)in the treatment of acute mastitis during lactation.Methods:Forty-three patients with acute mastitis during lactation were included in the study,who were given QJD orally.The severity index of mastitis,body temperature,breast pain score,body surface area of breast mass,patency of milk,chapped nipple,TCM whole body symptom score and safety index were observed before and after treatment.Results:The total effective rate of treatment was 97.67%(42/43).There were significant differences in the severity index,body temperature,breast pain score,breast mass surface area,milk patency,nipple cracking,and TCM whole body symptom score before and after treatment(P<0.01).During the treatment,2 lactating infants developed diarrhea,and the symptoms disappeared after the medication was stopped.Conclusion:Qingre Jiedu decoction is safe and effective in treating acute mastitis during lactation,and is worthy of clinical promotion and application.

关 键 词：清热解毒汤 哺乳期 乳腺炎 

分 类 号：R271.44[医药卫生—中医妇科学]