玉液汤联合常规降糖措施治疗2型糖尿病合并失眠患者疗效观察  

Observation of the Efficacy of Yuye Decoction Combined with Conventional Hypoglycemic Measures in Treating Patients with Type 2 Diabetes Mellitus and Insomnia

作　　者：曹珣 刘影哲[3] 冯亚兰[3] CAO Xun;LIU Yingzhe;FENG Yalan(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The First Affiliated Hospital of Harbin Medical University,Harbin 150007,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]哈尔滨医科大学附属第一医院,黑龙江哈尔滨150007 [3]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中医药学报》2024年第10期72-77,共6页Acta Chinese Medicine and Pharmacology

基　　金：国家中医药管理局全国名老中医专家传承工作室建设项目(国中医人教函〔2022〕75号);黑龙江省博士后基金项目(LBH-Z19209);黑龙江省中医药科研项目(2018-041)。

摘　　要：目的:探究玉液汤联合常规降糖措施治疗2型糖尿病合并失眠的疗效及安全性。方法:随机选取2023年6月—2024年6月黑龙江中医药大学附属第一医院内分泌科120例2型糖尿病合并失眠患者,将其随机分为联合组和对照组,每组60例(对照组1例自愿退出作脱落处理)。联合组和对照组降糖基础上分别加用玉液汤和艾司唑仑治疗。比较两组血糖指标、匹兹堡睡眠量表(PSQI)、中医证候量表、临床有效率及不良反应发生率。结果:两组治疗后FBG和2 h PG显著降低(P<0.01),与对照组比较,联合组降低更明显(P<0.01)。两组PSQI总分治疗后及随访时均较治疗前降低(P<0.01),且治疗后及随访时联合组较对照组更低,差异具有统计学意义(P<0.01)。联合组与对照组有效率分别为80.0%(48/60)和69.49%(41/59),差异有统计学意义(P<0.01),两组患者均未诉明显不适。结论:对糖尿病合并失眠患者应用玉液汤联合常规降糖措施治疗,可有效平稳血糖,改善症状及睡眠状态,同时不会增加不良反应。Objective:To investigate the efficacy and safety of Yuye Decoction combined with conventional hypoglycemic measures in treating patients with type 2 diabetes mellitus and insomnia.Methods:A total of 120 patients with type 2 diabetes mellitus and insomnia were randomly selected from the Endocrinology Department of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine between June 2023 and June 2024.The patients were randomly divided into the Combination Group and the Control Group,with 60 patients in each group(one patient in the Control Group withdrew,leaving 59 patients).On top of basic hypoglycemic treatment,the Combination Group was treated with Yuye Decoction and the Control Group was treated with Estazolam.Blood glucose indicators,Pittsburgh Sleep Quality Index(PSQI)scores,Traditional Chinese Medicine syndrome scores,clinical efficacy rates,and the incidence of adverse reactions were compared between the two groups.Results:Both groups showed a significant reduction in Fasting Blood Glucose(FBG)and 2-hour Postprandial Glucose(2 h PG)before and after treatment(P<0.01),with a more pronounced reduction in the Combination Group compared to the Control Group(P<0.01).Both groups had decreased PSQI total scores after treatment and during follow-up compared to before treatment(P<0.01),with the Combination Group showing a statistically significant difference compared to the Control Group after treatment and follow-up(P<0.05).The effective rates for the Combination Group and the Control Group were 80.0%(48/60)and 69.49%(41/59),respectively,with a statistically significant difference(P<0.01).Both groups reported no significant adverse effects.Conclusion:The use of Yuye Decoction combined with conventional hypoglycemic measures in patients with diabetes and insomnia can effectively stabilize blood glucose,improve symptoms and sleep quality,without increasing adverse reactions.

关 键 词：2型糖尿病 失眠 玉液汤 补充医学 

分 类 号：R256.23[医药卫生—中医内科学]