自拟六味更年安治疗肝肾阴虚型更年期综合征80例疗效观察  

Observational Study on the Effectiveness of Self-Formulated Liuwei Gengnianan in Treating 80 Cases Liver and Kidney Yin Deficiency Type Menopausal Syndrome

作　　者：韩一益 袁艳红 HAN Yiyi;YUAN Yanhong(Yancheng Hospital of Traditional Chinese Medicine,Yancheng 224001,China)

机构地区：[1]盐城市中医院,江苏盐城224001

出　　处：《中医药学报》2024年第10期88-92,共5页Acta Chinese Medicine and Pharmacology

基　　金：江苏省自然科学基金项目(BK20221436)。

摘　　要：目的:观察自拟六味更年安治疗肝肾阴虚型更年期综合征80例的疗效。方法:选择2021年1月—2022年11月在盐城市中医院诊治的肝肾阴虚型更年期综合征患者80例为研究对象,采用随机数字表法分为对照组和观察组,每组40例,对照组采用常规西药治疗,观察组采用常规西药联合六味更年安治疗,比较两组患者治疗前后的激素[包括黄体生成素(LH)、促卵泡生成素(FSH)、雌二醇(E2)、抗苗勒管激素(AMH)]水平,治疗效果、临床症状分级量化积分、改良Kupperman评分及绝经期生存质量量表(MENQOL)评分,治疗前后肝肾功能和血液流变学参数以及不良反应。结果:治疗前,两组激素水平、肝肾功能、血液流变学参数以及临床症状分级量化积分、改良Kupperman评分、MENQOL评分比较差异无统计学意义(P>0.05),治疗后,两组LH及FSH水平均降低(P<0.05),且观察组低于对照组(P<0.01),E2、AMH水平均升高(P<0.05),且观察组高于对照组(P<0.05,P<0.01);治疗后,两组患者临床症状分级量化积分、改良Kupperman和MENQOL评分均降低(P<0.05),且观察组低于对照组(P<0.01);观察组总有效率高于对照组(P<0.01);治疗后两组谷草转氨酶(AST)、谷丙转氨酶(ALT)、尿素氮(BUN)、肌酐(Cre)、血浆黏度(PV)、红细胞聚集指数(RCAI)均下降(P<0.05),且观察组低于对照组(P<0.05,P<0.01)。两组患者治疗期间均未出现肠胃不适、恶心、呕吐、浮肿、肝肾损伤等不良反应。结论:自拟六味更年安在改善激素水平和肝肾功能方面效果显著,并且可以提高患者生活质量,值得推广。Objective:To observe the therapeutic effectiveness of self-formulated Liuwei Gengnianan on 80 cases of menopausal syndrome characterized by liver and kidney yin deficiency.Methods:Eighty patients diagnosed with liver and kidney yin deficiency type of menopausal syndrome from January 2021 to November 2022 at Yancheng Hospital of Traditional Chinese Medicine were selected and randomly divided into a control group and an observation group,with 40 patients in each.The control group received conventional Western medicine treatment,while the observation group received a combination of conventional Western medicine and Liuwei Gengnianan.The study compared hormone levels(including Luteinizing Hormone[LH],Follicle-Stimulating Hormone[FSH],Estradiol[E2],and Anti-Müllerian Hormone[AMH]),treatment outcomes,clinical symptom grading quantitative scores,modified Kupperman scores,and Menopause-Specific Quality of Life(MENQOL)scores before and after treatment.Liver and kidney function,hemorheological parameters,and adverse reactions were also monitored.Results:Before treatment,there were no significant differences between the two groups in terms of hormone levels,liver and kidney functions,hemorheological parameters,and scores for clinical symptom grading,modified Kupperman,and MENQOL(P>0.05).Post-treatment,LH and FSH levels decreased(P<0.05),with lower levels in the observation group(P<0.01),while E2 and AMH levels increased(P<0.05),higher in the observation group(P<0.05,P<0.01).The clinical symptom grading scores,modified Kupperman,and MENQOL scores decreased in both groups(P<0.05),with lower scores in the observation group(P<0.01).The total effective rate was higher in the observation group(P<0.01).Post-treatment,levels of Aspartate Aminotransferase(AST),Alanine Aminotransferase(ALT),Blood Urea Nitrogen(BUN),Creatinine(Cre),Plasma Viscosity(PV),and Red Cell Aggregation Index(RCAI)decreased(P<0.05),with lower levels in the observation group(P<0.05,P<0.01).No adverse reactions such as gastrointestinal discomfort,nausea,vomiting

关 键 词：六味更年安 更年期综合征 安全性 临床症状分级量化积分 

分 类 号：R271.116[医药卫生—中医妇科学]