血清LMNA、LTB4对妊娠期高血压疾病患者妊娠不良结局的诊断价值  

Diagnostic value of serum LMNA and LTB4 for adverse pregnancy outcomes in patients with hypertensive disorders of pregnancy

作　　者：李妮 王彩梅 寇帅 LI Ni;WANG Caimei;KOU Shuai(Department of Obstetrics Gynaecology,Yulin Hospital,the First Affiliated Hospital of Xi'an Jiaotong University,Yulin,Shaanxi 719000,China)

机构地区：[1]西安交通大学第一附属医院榆林医院妇产科,陕西榆林719000

出　　处：《国际检验医学杂志》2024年第19期2340-2344,共5页International Journal of Laboratory Medicine

基　　金：陕西省科学技术研究发展计划(2020JM3016)。

摘　　要：目的探讨血清核纤层蛋白A(LMNA)、白三烯(LT)B4对妊娠期高血压疾病(HDP)患者妊娠不良结局的诊断价值。方法选取2021年1月至2023年5月该院收治的HDP患者83例为HDP组和同时间段83例健康孕妇为对照组,根据妊娠结局将HDP患者分为不良结局组(38例)和良好结局组(45例),采用酶联免疫吸附试验检测血清LMNA、LTB4水平。采用多因素Logistic回归分析HDP患者妊娠不良结局的影响因素,受试者工作特征(ROC)曲线分析血清LMNA、LTB4水平对HDP患者妊娠不良结局的诊断价值。结果与对照组比较,HDP组血清LMNA水平降低,LTB4水平升高(P<0.05);与良好结局组比较,不良结局组血清LMNA水平降低,LTB4水平升高(P<0.05)。子痫前期、重度子痫前期、LTB4水平升高为HDP患者妊娠不良结局的独立危险因素,LMNA水平升高为独立保护因素(P<0.05);血清LMNA、LTB4水平联合诊断HDP患者妊娠不良结局的曲线下面积为0.873,大于血清LMNA、LTB4水平单独诊断的0.787、0.786(P<0.05)。结论血清LMNA水平降低和LTB4水平升高与HDP患者妊娠不良结局有关,联合检测血清LMNA、LTB4水平对HDP患者妊娠不良结局的诊断价值较高。Objective To investigate the diagnostic value of serum lamin A(LMNA)and leukotriene(LT)B4 for adverse pregnancy outcomes in patients with hypertensive disorders of pregnancy(HDP).Methods A total of 83 HDP patients admitted to the hospital from January 2021 to May 2023 were selected as the HDP group and 83 healthy pregnant women in the same period were selected as the control group.According to the pregnancy outcome,the HDP patients were divided into a poor outcome group(38 cases)and a good outcome group(45 cases).Serum LMNA and LTB4 levels were measured by enzyme-linked immunosorbent assay.Multivariate Logistic regression was used to analyze the influencing factors of adverse pregnancy outcomes in patients with HDP.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum LMNA and LTB4 levels for adverse pregnancy outcomes in patients with HDP.Results Compared with the control group,the serum LMNA level was decreased and the LTB4 level was increased in the HDP group(P<0.05).Compared with the good outcome group,the serum LMNA level was significantly decreased,and the LTB4 level was increased in the poor outcome group(P<0.05).Preeclampsia,severe preeclampsia and elevated LTB4 level were independent risk factors for adverse pregnancy outcomes in patients with HDP,and elevated LMNA level was an independent protective factor(P<0.05).The area under the curve of serum LMNA and LTB4 levels in the diagnosis of adverse pregnancy outcomes of HDP patients was 0.873,which was larger than 0.787 and 0.786 of serum LMNA and LTB4 levels alone(P<0.05).Conclusion Decreased serum LMNA and increased LTB4 levels are associated with adverse pregnancy outcomes in patients with HDP.Combined detection of serum LMNA and LTB4 levels have a high diagnostic value for adverse pregnancy outcomes in patients with HDP.

关 键 词：妊娠期高血压疾病 核纤层蛋白A 白三烯B4 妊娠不良结局 

分 类 号：R714.7[医药卫生—妇产科学]