2型糖尿病合并急性脑梗死患者血清ADA、 SERPINE1水平及临床意义  

Serum ADA and SERPINE1 levels and their clinical significance in patients with type 2 diabetes mellitus and acute cerebral infarction

作　　者：黄江波 王建 邵英 HUANG Jiangbo;WANG Jian;SHAO Ying(Department Emergency,Xi'an Labor Union Hospital,Xi'an,Shaanxi 710100,China;Department of Endocrinology,Air Force Military Medical University Xijing 986 Hospital,Xi'an,Shaanxi 710054,China)

机构地区：[1]西安工会医院急诊科,陕西西安710100 [2]空军军医大学西京986医院内分泌科,陕西西安710054

出　　处：《国际检验医学杂志》2024年第19期2354-2359,共6页International Journal of Laboratory Medicine

基　　金：陕西省自然科学基础研究计划(2019JM-422)。

摘　　要：目的 探讨2型糖尿病(T2DM)合并急性脑梗死(ACI)患者血清腺苷脱氨酶(ADA)、纤溶酶原激活物抑制因子1(SERPINE1)水平及预后预测价值。方法 选择2019年3月至2023年3月西安工会医院收治的195例T2DM合并ACI患者为ACI组和174例单纯T2DM患者为对照组。比较ACI组、对照组及不同神经缺损程度及预后患者血清ADA、SERPINE1水平,分析T2DM合并ACI患者预后不良影响因素,以及各指标预测预后不良的价值。结果 ACI组血清ADA、SERPINE1水平高于对照组(P<0.05)。随着T2DM合并ACI患者神经缺损程度加重,血清ADA、SERPINE1水平升高(P<0.05)。预后不良组血清ADA、SERPINE1水平高于预后良好组(P<0.05)。重度神经缺损及高水平ADA、SERPINE1、HbA1c是T2DM合并ACI患者预后不良的危险因素(P<0.05)。ADA、SERPINE1联合预测T2DM合并ACI患者预后的曲线下面积为0.896,高于单独预测(P<0.05)。结论 T2DM合并ACI患者血清ADA、SERPINE1水平升高与神经缺损程度较重和预后不良有关,联合检测可预测T2DM合并ACI患者预后不良。Objective To investigate the prognostic value of serum adenosine deaminase(ADA)and plasminogen activator inhibitor 1(SERPINE1)levels in patients with type 2 diabetes mellitus(T2DM)complicated with acute cerebral infarction(ACI).Methods A total of 195 patients with T2DM combined with ACI(ACI group)and 174 patients with T2DM alone(control group)admitted to Xi'an Labor Union Hospital from March 2019 to March 2023 were selected.The levels of serum ADA and SERPINE1 were compared between ACI group and control group,and patients with different degrees of neurological defect and prognosis.The influencing factors of poor prognosis in T2DM patients with ACI were analyzed,and the value of each index in predicting poor prognosis was evaluated.Results The levels of ADA and SERPINE1 in ACI group were significantly higher than those in control group(P<0.05).With the aggravation of neurological deficit in T2DM patients with ACI,serum ADA and SERPINE1 levels increased(P<0.05).The levels of serum ADA and SERPINE1 in the poor prognosis group were higher than those in the good prognosis group(P<0.05).Severe neurological deficit and high levels of ADA,SERPINE1 and HbA1c were risk factors for poor prognosis in T2DM patients with ACI(P<0.05).The area under the curve(AUC)of ADA combined with SERPINE1 for predicting the prognosis of T2DM patients with ACI was 0.896,which was higher than that of Ada and SERPINE1 alone(P<0.05).Conclusion Elevated serum ADA and SERPINE1 levels are associated with severe neurological deficits and poor prognosis in T2DM patients with ACI.Combined detection of ADA and SERPINE1 can predict poor prognosis in T2DM patients with ACI.

关 键 词：2型糖尿病 急性脑梗死 腺苷脱氨酶 纤溶酶原激活物抑制因子1 

分 类 号：R587.1[医药卫生—内分泌]