基于SLM成形多孔支架力学性能研究及下颌骨假体设计  

STUDY ON MECHANICAL PROPERTIES OF POROUS SCAFFOLD AND DESIGNING OF MANDIBULAR PROSTHESIS BASED ON SLM FORMING

作　　者：阎汉生[1] 魏波 刘子龙 丘永亮[1] YAN HanSheng;WEI Bo;LIU Chris;QIU YongLiang(School of Mechanical and Electrical Engineering,Guangdong Polytechnic of Industry and Commerce,Guangzhou 510510,China;Growup Internet Co,Ltd,Vancouver V6L 2M9,Canada)

机构地区：[1]广东工贸职业技术学院机电工程学院,广州510510 [2]小禾互联网有限公司,温哥华V6L 2M9

出　　处：《机械强度》2024年第5期1152-1158,共7页Journal of Mechanical Strength

基　　金：2021年中国职业技术教育学会项目(2021B161)资助。

摘　　要：组织工程骨是修复大节段骨缺损的重要方法,但如何设计力学性能与宿主骨相匹配的假体仍有待研究。因此,本研究的目的是基于激光选区熔化(Selective Laser Melting,SLM)成形技术探索多孔支架的力学性能,并应用于下颌骨重建。首先,建立不同孔隙率(50%~80%)的六面体(Hexahedral,HE)、八面体(Octahedral,OC)、体心立方(Body Centred Cubic,BCC)单元结构的多孔支架模型,通过有限元模型分析支架的力学性能。其次,利用SLM成形技术制备力学性能强的多孔Ti6Al4V支架,结合压缩试验评估支架的力学性能。最后,利用最小二乘法拟合支架的孔隙率-弹性模量曲线,从而获得力学性能与下颌骨缺损区域相匹配的多孔假体。结果表明,多孔支架的峰值应力随着孔隙率的上升而上升,且与构型密切相关(BCC>OC>HE);压缩试验证明了不同孔隙率的支架的弹性模量存在显著差异性,且孔隙率与弹性模量成反比。根据六面体单元的Gibson-Ashby模型,计算得到理想的假体的孔隙率为53.1%,并且有限元分析验证了假体的安全性。通过有限元分析和压缩试验证实了不同孔隙率的支架力学性能存在差异,合适孔隙率的假体能够更好地匹配宿主骨的力学性能,为植入物设计提供一定的参考价值。The tissue engineered bone provides an important method for repairing large segmental bone defects.However,how to design a prosthesis that matches the mechanical properties of host bone remains to be studied.Therefore,this study aimed to explore the scaffold mechanical properties based on selective laser melting(SLM)fonning printing technology for scaffold and apply to mandibular reconstruction.Firstly,hexahedral(HE),octahedral(OC)and body centred cubic(BCC)unit cell porous scaffolds with different porosity(50%-80%)were established,and the porous scaffold mechanical properties were analyzed by finite element analysis.Secondly,the porous Ti6Al4V scaffolds with strong mechanical properties were prepared by SLM forming technology,and the scaffold mechanical properties were evaluated by the compression test.Finally,the least square method was used to fit the scaffold porosity⁃elastic modulus curve,so as to obtain the porous prosthesis with mechanical properties matching the mandibular defect region.The results show that the maximum stress of porous scaffold increases with the increase of porosity and is closely related to the configuration(BCC>OC>HE).The compression test shows that the scaffold elastic modulus with different porosities is significantly different,and the porosity is inversely proportional to the elastic modulus.According to the Gibson⁃Ashby model of hexahedral unit cell scaffold,the ideal prosthesis porosity is 53.1%.Additionally,the safety of the prosthesis is verified by finite element analysis.The finite element analysis and compression test confirmed that the scaffold mechanical properties with different porosities are discrepant,and the optimized prosthesis with appropriate porosity can better match the mechanical properties of host bone,which provides valuable insights for implant design.

关 键 词：激光选区融化 多孔支架 弹性模量 孔隙率 下颌骨假体 

分 类 号：R318.08[医药卫生—生物医学工程] TG665[医药卫生—基础医学]