Effects of ovarian response prediction index and follicle-oocyte index on pregnancy outcomes:a retrospective cohort study of 12,218 fresh transfer cycles  

作　　者：Mao Wang Li Tan Yu-Bin Ding Xiao-Jun Tang Tian Li Xin-Yue Hu Hu-Cen Zhong Qi Wan Zhao-Hui Zhong 

机构地区：[1]Department of Epidemiology,School of Public Health,Research Center for Medicine and Social Development,Innovation Center for Social Risk Governance in Health,Chongqing Medical University,Chongqing 400016,China [2]The Reproductive Center,Chengdu Xinan Gynecology Hospital,Chengdu 610011,China [3]Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China,School of Public Health,Chongqing Medical University,Chongqing 400016,China [4]Academician Workstation,Department of Pharmacology,Changsha Medical University,Changsha 410219,China [5]The Department of Reproductive Medicine,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China [6]Department of Gynecology and Obstetrics,West China Second Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Reproductive and Developmental Medicine》2024年第3期151-161,共11页生殖与发育医学（英文版）

摘　　要：Objective:To investigate the potential relationships among the ovarian response prediction index(ORPI),follicle-oocyte index(FOI),and clinical pregnancy rate(CPR)in women undergoing their first in vitro fertilization/intracytoplasmic sperm injectionembryo transfer(IVF/ICSI-ET)fresh cycle transfer.Methods:In this retrospective cohort study,we included 12,218 women who underwent their first IVF/ICSI-ET cycle between December 2014 and January 2021.The primary and secondary outcomes of our study were CPR and cumulative live birth rate(CLBR),respectively.The data were divided into three groups according to the ORPI and FOI tertiles.Multivariate logistic regression analyses,stratification analyses,interaction,restricted cubic splines,and receiver operating characteristic(ROC)curves were constructed to identify the relationships among ORPI,FOI,and CPR.Results:A statistically significant increase in CPR was detected from the lowest to the highest tertile group(ORPI:48.12%,54.07%,and 53.47%,P<0.001;FOI:49.99%,52.95%,and 52.71%,P=0.012).A higher CLBR was observed in the high group(ORPI:38.63%,44.62%,and 44.19%,P<0.001;FOI:41.02%,43.78%,and 42.59%,P=0.039).Multivariate logistic regression analysis revealed no statistically significant differences between ORPI,FOI,and neither CPR(odds ratio[OR][95%confidence interval{CI}],0.99[0.97–1.00]vs.[1.02{0.84–1.24}])nor CLBR(OR[95%CI],0.99[0.97–1.01]vs.0.99[0.81–1.20]).No significant association was found among FOI,ORPI,and CPR,even in the subgroups.Restricted cubic spline analyses indicated the existence of a non-linear relationship across the entire range of FOI and ORPI.The ORPI and FOI variables had poor predictive ability(AUC<0.60)for CPR.Conclusions:Both ORPI and FOI are not reliable predictors of clinical pregnancy or live birth outcomes in fresh ETs.Clinicians and researchers should avoid using FOI and ORPI to assess pregnancy outcomes after fresh ET because of their limited relevance and predictive value.

关 键 词：In vitro fertilization Controlled ovarian hyperstimulation Ovarian response indexes Ovarian response prediction index Follicle-oocyte index Clinical pregnancy 

分 类 号：R714.8[医药卫生—妇产科学]