Multiomics approaches to uncover endometrial receptivity in embryo implantation:a mini-review  

作　　者：Sudini R.Fernando Yang Yan Manish Kumar Hoi-Lam Lai Yin-Lau Lee Ernest H.Y.Ng William S.B.Yeung Kai-Fai Lee 

机构地区：[1]Department of Obstetrics and Gynaecology,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Pokfulam,Hong Kong SAR 999077,China [2]Department of Animal Science,Faculty of Animal Science and Export Agriculture,Uva Wellassa University,Badulla,Sri Lanka [3]Shenzhen Key Laboratory of Fertility Regulation,The University of Hong Kong-Shenzhen Hospital,Futian District,Shenzhen 518053,China

出　　处：《Reproductive and Developmental Medicine》2024年第3期178-185,共8页生殖与发育医学（英文版）

基　　金：supported by grants from the Sanming Project of Medicine in Shenzhen,China(SZSM201612083 to W.S.B.Y.);Shenzhen Key Medical Discipline(SZXK2020089);General Research Fund,Research Grants Council,Hong Kong(06173976 and 17120720 to K.F.L.);Health and Medical Research Fund,Hong Kong(06173976 to K.F.L.);Internal Research Funding from the Department of Obstetrics and Gynecology at the University of Hong Kong.

摘　　要：Successful implantation requires concerted interactions during the apposition,adhesion,and invasion of the embryo into a receptive endometrium.However,the embryo implantation rate for assisted reproduction remains low despite the transfer of good quality embryos.Changes in endometrial transcriptomics,proteomics,lipidomics,and even microbiota all play important roles in embryo implantation.Specifically,the expression of steroid hormone-regulated adhesive and anti-adhesive molecules during the embryo implantation window is becoming an area of increasingly intense research.This review(a)summarizes the different molecules expressed in the receptive endometrium and(b)proposes the use of surface protein markers to predict pregnancy outcomes from assisted reproduction.

关 键 词：Cell surface proteins Steroid regulation Endometrial receptivity Receptivity marker INFERTILITY 

分 类 号：R714.8[医药卫生—妇产科学]