Genetic factors of reproductive disorders in female  

作　　者：Inna I.Mordovina Alina K.Chebanu Maksim Y.Donnikov Tatiana A.Sinyukova Lyudmila V.Kovalenko Larisa D.Belotserkovtseva 

机构地区：[1]Department of Obstetrics,Gynecology,and Perinatology,Medical Institute of Surgut State University,Surgut,Russian Federation [2]Scientific and Educational Center,Medical Institute of Surgut State University,Surgut,Russian Federation [3]Department of Pathophysiology and General Pathology,Director of the Medical Institute,Surgut State University,Surgut,Russian Federation [4]Surgut Regional Clinical Center for Maternity and Childhood Protection,Surgut,Russian Federation

出　　处：《Reproductive and Developmental Medicine》2024年第3期186-195,共10页生殖与发育医学（英文版）

基　　金：supported by Project No.15.BRK.21.008 Multicenter Research Bioresource Collection“Human Reproductive Health”(Agreement No.075-15-2021-1058 dated September 28,2021);funded by the Ministry of Science and Higher Education of the Russian Federation.

摘　　要：Successful reproduction in mammals requires gamete development,fertilization,and early embryonic development.Defects in any of these processes can lead to infertility,recurrent miscarriages,and congenital defects.The clinical recognition of the genetic causes of female reproductive insufficiency using increasingly advanced genetic technologies poses a serious challenge for reproductive medicine in the 21st century.Herein,the current literature on genetic factors involved in reproductive losses was summarized.A literature search was conducted using Web of Science,MEDLINE,and PubMed databases for articles written in English on the genetic causes of women’s reproductive health disorders.Future implementation of whole-exome and wholegenome sequencing is expected to identify numerous genetic factors responsible for oocyte quality.Which will aid in increasing the likelihood of successful female reproductive function,improve the outcomes of assisted reproductive technologies,optimize treatment,and facilitate genetic diagnosis of patients.

关 键 词：GENETICS INFERTILITY Reproductive disorders Premature ovarian insufficiency 

分 类 号：R711.6[医药卫生—妇产科学]