白塞病生物标志物研究进展  

Research progress of biomarkers in Behcet′s disease

作　　者：詹皓婷 李永哲[1] Zhan Haoting;Li Yongzhe(Department of Clinical Laboratory,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Science,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院检验科,北京100730

出　　处：《中华检验医学杂志》2024年第9期1106-1114,共9页Chinese Journal of Laboratory Medicine

基　　金：国家重点发展计划(2018YFE0207300);北京市自然科学基金(7234383);中央高水平医院临床科研业务(2022-PUMCH-B-124);中国博士后科学基金(2023T160060)。

摘　　要：白塞病是一种以口-眼-生殖器为临床三联征的可变性血管炎,累及动静脉、关节、胃肠道和神经时会造成患者生活质量降低甚至死亡。目前尚缺乏白塞病实验室诊断标志物,寻找与疾病表型、活动度、严重度相关,能应用于早期预警、治疗反应监测和预后评估等方面的生物标志物势在必行。该文重点探讨白塞病生物标志物临床研究进展,明确每种指标在发病机制中的作用,并对未来研究方向进行了相应展望。Behcet′s disease is a variable vasculitis characterized by oral aphthous ulcers,ocular lesions and genital ulcers with involvement of arteries,veins,joints,gastrointestinal tract and nerves,resulting in reduced quality of life and even death.The lack of laboratory diagnostic markers for Behcet′s disease,necessitates the identification of biomarkers that correlate with disease phenotype,activity and severity.These biomarkers are crucial for advanced warning,treatment response,monitoring and prognosis assessment.This article reviews recent advances in clinical research on biomarkers for Behcet′s disease,clarifies the role of each biomarker in the pathogenesis of Behcet′s disease,and provides corresponding prospects for future research directions.

关 键 词：贝赫切特综合征 自身抗体 基因 生物标志物 诊断 

分 类 号：R597.9[医药卫生—内科学]