肝脏MRI精准定量分析基于“调和致中”理论穴位埋线治疗单纯性肥胖的临床研究  

Clinical study on liver MRI based on the theory of‘harmonization and neutralization'for precise quantitative analysis of acupoint catgut embedding in simple obesity

作　　者：李晓民 张帆[1] 阮静茹[1] 李奎武 朱敬伟 胡培佳 吴睿[2] 靳恒军 甄振华[2] 李向梅[2] 何荣芬 蔡荣林[1,4] 储浩然[3,5,6] LI Xiaomin;ZHANG Fan;RUAN Jingru;LI Kuiwu;ZHU Jingwei;HU Peijia;WU Rui;JIN Hengjun;ZHEN Zhenhua;LI Xiangmei;HE Rongfen;CAI Ronglin;CHU Haoran(Anhui University of Chinese Medicine,Hefei 230031,China;Huaibei People's Hospital,Huaibei 235000,China;The Second Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230061,China;Xin'an Medical and Chinese Medicine Modernization Research Institute,Hefei Comprehensive National Science Center,Hefei 230038,China;Clinical Research Institute of Acupuncture and Moxibustion,Anhui Academy of Traditional Chinese Medicine,Hefei 230038,China;Anhui Acupuncture and Moxibustion Clinical Medical Research Center,Hefei 230061,China)

机构地区：[1]安徽中医药大学,合肥230031 [2]淮北市人民医院,淮北235000 [3]安徽中医药大学第二附属医院,合肥230061 [4]合肥综合性国家科学中心新安医学与中医药现代化研究所,合肥230038 [5]安徽省中医药科学院针灸临床研究所,合肥230038 [6]安徽省针灸临床医学研究中心,合肥230061

出　　处：《中华中医药杂志》2024年第9期5083-5088,共6页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：储浩然全国名老中医药专家传承工作室(No.国中医药人教函[2022]75号);安徽省中医药领军人才(No.中医药发展秘[2018]23号);2022年度安徽省卫生健康科研项目(No.AHWJ2022c045);合肥综合性国家科学中心大健康研究院新安医学与中医药现代化研究所“揭榜挂帅”项目(No.2023CXMMTCM019)。

摘　　要：目的:观察基于“调和致中”理论穴位埋线对单纯性肥胖患者的临床疗效。方法:98例单纯性肥胖患者根据随机数表法分为穴位埋线组(49例,脱落15例,剔除5例,最终入组29例)和营养管理组(49例,脱落11例,剔除9例,最终入组29例)。营养管理组给予单纯的营养管理治疗,时间为6周。穴位埋线组在穴位埋线的基础上给予营养管理,2周1次穴位埋线治疗,共治疗3次。治疗前后对患者进行肝脏MRI精准定量分析,利用LiverLab系统精准分析治疗前后肝脏脂肪含量、R2^(*)值的变化,计算以脐为平面的腹壁厚度,比较身体质量指数(BMI)、体质量、腰臀比、体脂百分比(PBF)等。结果:穴位埋线组治疗后体质量、肝脏脂肪含量、BMI、R2^(*)值、腰臀比、以脐为平面的腹壁厚度、PBF均较治疗前显著降低(P<0.05,P<0.01);营养管理组治疗后R2^(*)值、腰臀比、PBF均较治疗前显著降低(P<0.05)。两组比较治疗前后体质量、肝脏脂肪含量、BMI、R2^(*)值等指标,以及治疗前后差值、治疗前后差值百分比,差异均有统计学意义(P<0.05,P<0.01)。结论:穴位埋线可显著降低单纯性肥胖患者的肝脏脂肪含量、R2^(*)值,减少腹部脂肪厚度。Objective:To observe the clinical effect of acupoint catgut embedding on patients with simple obesity based on the theory of harmonization and centralization'.Methods:A total of 98 patients with simple obesity were divided into acupoint catgut embedding group(49 cases,15 cases fell off,5 cases were eliminated,and 29 cases were eventually enrolled)and nutrition management group(49 cases,1l cases fell off,9 cases were eliminated,and 29 cases were eventually enrolled)according to random number table method.The nutrition management group was given simple nutrition management therapy for 6 weeks.The acupoint catgut embedding group was given nutritional management on the basis of acupoint catgut embedding,once every two weeks acupoint catgut embedding therapy,and a total of three treatments were performed.At the same time,liver MRI precise quantification analysis was performed on patients before and after treatment,LiverLab system was used to accurately analyze the changes of liver fat content and R2^(*)value before and after treatment,and abdominal wall thickness with umbilical plane was calculated.Body mass index(BMI),body mass,waist-to-hip ratio,and percentage of body fat(PBF)were compared.Results:Body mass,liver fat content,BMI,R2 value,waist-to-hip ratio,umbilical abdominal wall thickness and PBF were significantly decreased in acupoint catgut embedding group before and after treatment(P<0.05,P<0.01).In the nutrition management group,R2^(*)value,waist-to-hip ratio and PBF after treatment were significantly lower than those before treatment(P<0.05).There were statistical significance in body mass,liver fat content,BMI,R2^(*)value,differences in various indicators before and after treatment,and percentage difference before and after treatment between the two groups(P<0.05,P<0.01).Conclusion:Acupoint catgut embedding can significantly reduce liver fat content,R2^(*)value,and abdominal wall thickness with umbilical plane in patients with simpleobesity.

关 键 词：穴位埋线 肝脏MRI精准定量分析 R2^(*) 营养管理 调和致中 

分 类 号：R246.1[医药卫生—针灸推拿学]