甲状腺激素对妊娠妇女免疫功能及妊娠结局影响分析  

Effect of thyroid hormone on immune function and pregnancy outcome in pregnant women

作　　者：朱树国[1] 张静 王同 游聚敏 ZHU Shuguo;ZHANG Jing;WANG Tong;YOU Jumin(Department of Obstetrics,Heze Municipal Hospital,Heze 274000,China)

机构地区：[1]菏泽市立医院产科,菏泽274000

出　　处：《国际免疫学杂志》2024年第4期360-364,共5页International Journal of Immunology

摘　　要：目的探究不同甲状腺激素水平对妊娠妇女免疫功能及妊娠结局的影响。方法选取菏泽市立医院妇产科2022年1月至2022年12月期间就诊的150例孕妊娠妇女为研究对象, 所有研究对象均接受甲状腺激素水平及免疫功能相关检测。依据甲状腺激素水平分为甲亢组(32例), 甲减组(41例)和正常组(77例)。电化学发光法测定游离甲状腺素(free thyroxine, FT4)、游离三碘甲状腺原氨酸(free triiodothyronine, FT3)、促甲状腺素(thyroid-stimulatinghormone, TSH);免疫比浊法检测免疫球蛋白(immunoglobulin, Ig)M、IgG、IgA水平;流式细胞仪测定CD4^(+)、CD8^(+)细胞水平并计算CD4^(+)/CD8^(+)比值;统计分析甲亢组、甲减组和正常组血清学指标及妊娠结局的差异。结果甲亢组, 甲减组和正常组妇女的TT4、FT3、TSH水平差异均具有统计学意义[mmol/L:(25.89±2.15)比(12.56±2.56)、(14.89±2.11);pmol/L:(7.01±1.05)比(3.06±0.89)、(3.62±0.59);mIU/L:(2.26±0.45)比(13.87±1.59)、(2.78±0.52), F值分别为361.28、264.21、2219.25, P值均<0.05];甲亢组、甲减组、正常组的IgM、IgG、IgA、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平差异均具有统计学意义[g/L:(1.69±0.22)比(1.04±0.26)、(1.22±0.15);g/L:(10.92±1.56)比(9.16±1.52)、(9.77±1.36);g/L:(1.84±0.36)比(1.35±0.45)、(1.62±0.37);%:(37.89±4.56)比(31.26±4.15)、(34.06±4.15);%:(34.26±4.96)比(27.26±4.15)、(30.26±4.26);(1.45±0.16)比(0.91±0.11)、(1.12±0.15);F值分别为99.49、13.50、14.46、21.99、22.87、129.59, P值均<0.05];甲亢组、甲减组、正常组妇女不良妊娠结局发生率差异具有统计学意义[31.25%比31.71%比3.90%, χ^(2)=19.94, P<0.05];甲状腺激素、免疫功能与妊娠结局呈正相关(r值分别为0.689、0.745、0.569、0.623、0.687、0.645、0.745、0.699、0.612, P值均<0.05)。结论甲状腺激素水平异常对妊娠期女性免疫功能及妊娠结局有影响, 及时进行处理可能提高妊娠妇女生育质量, 保障母婴身�Objective To explore the effects of different thyroid hormone levels on immune function and pregnancy outcome in pregnant women.Methods Total of 150 pregnant women admitted in Obstetrics Department of Heze Municipal Hospital from January 2022 to December 2022 were selected as the study subjects.Thyroid hormone level and immune function were tested,and according to thyroid hormone level,they were divided into hyperthyroidism group(32 cases),hypothyroidism group(41 cases)and normal group(77 cases).Free thyroxine(TT4),free triiodothyronine(FT3)and thyroid-stimulatinghormone(TSH)were determined by electrochemiluminescence.The levels of immunoglobulin(Ig)M,IgG and IgA were detected by immunoturbidimetry.The levels of CD4^(+)and CD8^(+)cells were measured by flow cytometry and the ratio of CD4^(+)/CD8^(+)was calculated.The differences of serological indexes and pregnancy outcome between hyperthyroidism group,hypothyroidism group and normal group were statistically analyzed.Results The levels of TT4,FT3 and TSH in hyperthyroidism group,hypothyroidism group and normal group were significantly different[mmol/L:(25.89±2.15)vs(12.56±2.56),(14.89±2.11);(7.01±1.05)vs(3.06±0.89),(3.62±0.59);mIU/L:(2.26±0.45)vs(13.87±1.59),(2.58±0.52),F value were 361.28,264.21,2219.25,respectively,all P values<0.05].The levels of IgM,IgG,IgA,CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)in hyperthyroidism,hypothyroidism and normal groups were significantly different[g/L:(1.69±0.22)vs(1.04±0.26),(1.22±0.15);g/L:(10.92±1.56)vs(9.16±1.52),(9.77±1.36);g/L:(1.84±0.36)vs(1.35±0.45),(1.62±0.37);%:(37.89±4.56)vs(31.26±4.15),(34.06±4.15);%:(34.26±4.96)vs(27.26±4.15),(30.26±4.26);(1.45±0.16)vs.(0.91±0.11),(1.12±0.15);F values were 99.49,13.50,14.46,21.99,22.87 and 129.59,respectively,all P values<0.05].The incidence of adverse pregnancy outcome in hyperthyroidism group,hypothyroidism group and normal group was statistically significant[31.25%vs 31.71%vs 3.90%,χ^(2)=19.94,P<0.05].Thyroid hormone and immune function were positively correla

关 键 词：甲状腺激素 妊娠妇女 免疫功能 妊娠结局 

分 类 号：R714[医药卫生—妇产科学]