耐受性树突状细胞的诱导机制与哮喘治疗  

Induction mechanisms of tolerogenic dendritic cells and asthma therapy

作　　者：黄思思 聂汉祥[1] HUANG Sisi;NIE Hanxiang(Department of Respiratory and Medicine,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院呼吸内科,武汉430060

出　　处：《国际免疫学杂志》2024年第4期441-445,共5页International Journal of Immunology

摘　　要：树突状细胞(dendritic cells, DCs)是异质性固有免疫细胞, 具有强大的抗原提呈能力。目前发现DCs可以调节机体对环境抗原及自身抗原的适应性免疫反应, 但在一定的微环境下, DCs还可以分化为耐受性DCs(tolerogenic DCs, tolDCs), 诱导免疫耐受。文章就耐受性DCs的产生机制与哮喘治疗进行综述, 为DCs应用于治疗哮喘及其他自身免疫性疾病的研究提供新思路。Dendritic cells(DCs)are a heterogeneous group of innate immune cells with a strong antigen presentation capacity.At present,it has been found that DCs can regulate the body's adaptive immune response to environmental antigens and autoantigens,but in a certain microenvironment,DCs can also differentiate into tolerant dendritic cells(tolerogenic DCs,tolDCs)to induce immune tolerance.This review summarizes the production mechanism of tolerogenic DCs and asthma treatment,and provides new ideas for the application of DCs in the treatment of asthma and other autoimmune diseases.

关 键 词：树突状细胞 免疫耐受 过敏性哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]