Impact of gonadotropin-releasing hormone agonist and hormone replacement therapy on pregnancy outcomes in single euploid frozen-thawed embryo transfer for patients with endometrial polyps  

作　　者：Qing Zhao Jie Li Wei-Lin Wang Ying-Bo Liu Jing Li Tian-Xiang Ni Wei Zhou Qian Zhang Jun-Hao Yan 

机构地区：[1]Center for Reproductive Medicine,Shandong University,Jinan 250012,China [2]State Key Laboratory of Reproductive Medicine and Offspring Health,Shandong University,Jinan 250012,China [3]Key Laboratory of Reproductive Endocrinology of Ministry of Education,Shandong University,Jinan 250012,China [4]Shandong Key Laboratory of Reproductive Medicine,Jinan 250012,China [5]Shandong Provincial Clinical Research Center for Reproductive Health,Jinan 250012,China [6]Shandong Technology Innovation Center for Reproductive Health,Jinan 250012,China [7]National Research Center for Assisted Reproductive Technology and Reproductive Genetics,Shandong University,Jinan 250012,China

出　　处：《Reproductive and Developmental Medicine》2024年第1期1-7,共7页生殖与发育医学（英文版）

基　　金：This study was funded by Key R&D Program of Shandong Province(2021LCZX02);National Key Research and Development Program(2021YFC2700604,2022YFC2703202);General Program of National Natural Science Foundation of China(82171648);Taishan Scholars Program for Young Experts of Shandong Province(tsqn201812154);Youth Program of National Natural Science Foundation of China(82101752);Youth Program of Shandong Provincial Natural Science Foundation of China(ZR2021QH075);General Program of Shandong Provincial Natural Science Foundation of China(ZR2022MH087) for data fee(scientific research informed consent,etc.),paper modification,and publication fee,etc.

摘　　要：Objective:Although consensus on the optimal endometrial preparation protocol for frozen-thawed embryo transfer(FET)is lacking,this is particularly true for patients with infertility and a history of endometrial polyps(EPs).In this study,we aimed to investigate whether a gonadotropin-releasing hormone agonist combined with hormone replacement therapy(GnRHa-HRT)could improve pregnancy outcomes in single euploid FET for patients with a history of EPs.Methods:In this retrospective cohort study,395 women who underwent their first single euploid FET cycle were divided into groups according to endometrial preparation protocols as follows:natural cycle(NC)(n=220),hormone replacement therapy(HRT)(n=122),and GnRHa-HRT groups(n=53).Subsequently,the FET cycles in the three groups were subdivided according to maternal age.All patients underwent hysteroscopic polypectomy before FET,and their EPs were confirmed by pathology.Results:No statistically significant differences were observed in live birth rates among the three groups(58.64%vs.58.20%vs.56.60%,P=0.964).Furthermore,the rates of miscarriage,ectopic pregnancy,premature live birth,and pregnancy complications were comparable among the three groups(P>0.05).After adjusting for potential confounding factors,no significant differences in pregnancy outcomes were reported between the groups(adjusted odds ratios[OR]and 95%credible intervals[CI]for live birth rate,HRTvs.NC:1.119,0.660–1.896,P=0.677;GnRHa-HRTvs.NC:1.165,0.610–2.226,P=0.643).Additionally,the pregnancy outcomes of the FET cycle were not influenced by the endometrial preparation protocols in the subgroups when stratified by maternal age(P>0.05).Conclusion:GnRHa-HRT did not improve the pregnancy outcomes of the single euploid FET in patients with a history of EPs.

关 键 词：Endometrial polyps Frozen-thawed embryo transfer GNRHA Hormone replacement therapy Preimplantation genetic testing 

分 类 号：R714.8[医药卫生—妇产科学]