中国首例拉沙热病例报道  

The first case of Lassa fever in China

作　　者：冉启惠 陈红 黄亮 孟令彬 陈竹 任利红 杜清 张钉山 李晨曦 郑永利 Ran Qihui;Chen Hong;Huang Liang;Meng Lingbin;Chen Zhu;Ren Lihong;Du Qing;Zhang Dingshan;Li Chenxi;Zheng Yongli(Department of Critical Care Medicine,Public Health Clinical Center of Chengdu,Sichuan Chengdu 610066,China;Department of Science and Education Division,Public Health Clinical Center of Chengdu,Sichuan Chengdu 610066,China;Department of Radiology,Public Health Clinical Center of Chengdu,Sichuan,Sichuan Chengdu 610066,China;Drug Clinical Trial Institutions,Public Health Clinical Center of Chengdu,Sichuan Chengdu 610066,China)

机构地区：[1]成都市公共卫生临床医疗中心重症医学科,四川成都610066 [2]成都市公共卫生临床医疗中心科研教学部,四川成都610066 [3]成都市公共卫生临床医疗中心放射科,四川成都610066 [4]成都市公共卫生临床医疗中心药物临床试验机构,四川成都610066

出　　处：《新发传染病电子杂志》2024年第4期1-5,共5页Electronic Journal of Emerging Infectious Diseases

基　　金：四川省医学青年创新科研课题计划(Q19068);成都市卫生健康委员会医学科研课题(2022264)。

摘　　要：拉沙热(Lassa fever)是一种由拉沙病毒(Lassa virus,LASV)引起的发热性传染病。该疾病于1969年在尼日利亚首次被报告,后在西非地区流行。LASV主要通过大鼠的尿液或粪便传播给人类,也可能通过接触感染者的血液、粪便或其他身体分泌物在人与人之间传播。拉沙热常见症状包括发热、头痛、呕吐、腹痛和咳嗽。本文报道了中国首例确诊拉沙热病例,该病例发病前曾在西非几内亚工作,发病后LASV血清荧光定量PCR检测和IgG抗体检测均为阳性,确诊拉沙热。确诊后,患者接受了利巴韦林联合对症支持治疗,病情逐渐好转。本研究全面回顾了该病例的流行病学史、临床症状、诊断过程、治疗措施及转归,以提高医务人员对拉沙热的认识和防治水平。通过对本病例的深入分析,为未来类似病例的快速识别与有效应对提供科学依据,促进公共卫生体系对输入性传染病防控能力的提升。Lassa fever is a febrile infectious disease caused by the Lassa virus(LASV).This disease was first reported in Nigeria in 1969 and subsequently became endemic in the West African region.LASV is mainly transmitted to humans through urine or feces of rats and may also be transmitted from person to person through contact with the blood,feces,or other bodily secretions of infected persons.Common symptoms of Lassa fever include fever,headache,vomiting,abdominal pain and cough.This article reports on the first confirmed case of Lassa fever in China,where the patient had been working in Guinea,West Africa,prior to the onset of the disease.After the onset,both the Lassa virus serum fluorescent quantitative PCR test and the IgG antibody test were positive,confirming the diagnosis of Lassa fever.Following the diagnosis,the patient received treatment with ribavirin in combination with symptomatic supportive therapy,which led to a gradual improvement in condition.The article provides a comprehensive review of the case's epidemiological history,clinical symptoms,diagnostic process,treatment measures,and outcome,with the hope of raising medical staff and vigilance about this infectious disease.Through an in-depth analysis of this case,the article summarizes the lessons learned and offers a scientific basis for the rapid identification and effective response to similar cases in the future,thereby enhancing the public health system's capacity to prevent and control the importation of infectious diseases.

关 键 词：拉沙热 临床症状 流行病学 诊断 治疗 预防 

分 类 号：R512.8[医药卫生—内科学]