120例女性宫颈病变患者HPV感染的基因型分布和病理特征分析  

Analysis of HPV infection,genotypes distribution and pathological characteristics in 120 female patients with cervical lesions

作　　者：王丽萍 张月 孙滨州 王岩岩 Wang Liping;Zhang Yue;Sun Binzhou;Wang Yanyan(The Second Department of Gynecology,Qinhuangdao Maternal and Child Health Hospital,Hebei Qinhuangdao 066000,China)

机构地区：[1]秦皇岛市妇幼保健院妇二科,河北秦皇岛066000

出　　处：《新发传染病电子杂志》2024年第4期23-28,共6页Electronic Journal of Emerging Infectious Diseases

基　　金：河北省卫生健康委员会(20221621);秦皇岛市重点研发计划科技支撑项目(20211112)。

摘　　要：目的分析120例女性宫颈病变患者人乳头状瘤病毒(human papilloma virus,HPV)感染情况、基因型分布和病理特征,以期指导临床治疗。方法回顾性分析2019年1月至2024年2月秦皇岛市妇幼保健院收治的120例女性宫颈病变患者的临床资料,所有患者均行病理学检查、HPV感染及基因型检测,分析HPV感染、基因型分布和病理特征。结果120例女性宫颈病变患者HPV感染率为51.67%(62/120)。62例HPV感染者低危型34例(54.84%),高危型28例(45.16%)。低危HPV基因型以HPV 6为主,占比为35.48%(22/62);高危HPV基因型以HPV 16、HPV 18为主,占比分别为17.74%(11/62)、12.90%(8/62)。病理结果显示,120例患者中慢性炎症者48例(40.00%)、低级宫颈上皮内瘤变34例(28.33%)、高级宫颈上皮内瘤变30例(25.00%)、宫颈癌8例(6.67%);不同病理类型宫颈病变组在临床症状和体征、HPV感染、病毒载量、基因型分布中的差异有统计学意义(P<0.05)。结论120例宫颈病变患者HPV感染率处于较高水平,尤以HPV 6、HPV 16、HPV 18基因型感染率更高,且不同病理分型宫颈病变在临床症状和体征、HPV感染情况、病毒载量、基因型分布方面存在差异,临床可据此制定和实行针对性防治措施。Objective To analyze human papilloma virus(HPV)infection,genotypes distribution and pathological characteristics in the 120 female patients with cervical lesions.Method A retrospective analysis was performed on the clinical data of 120 female patients with cervical lesions in Qinhuangdao Maternal and Child Health Hospital between January 2019 and February 2024.All patients underwent pathological examination,HPV infection and genotypes detection to analyze HPV infection,genotypes distribution and pathological characteristics.Result In the 120 patients,incidence of HPV infection was 51.67%(62/120).Among the 62 infection patients,there were 34 cases(54.84%)with lowrisk type and 28 cases(45.16%)with high-risk type.In low-risk HPV,incidence of HPV 6 genotype infection was the highest[35.48%(22/62)].In high-risk HPV,incidence of HPV 16 and HPV 18 genotypes infection was the highest[17.74%(11/62),12.90%(8/62)].Pathological results showed that in the 120 patients,there were 48 cases(40.00%)with chronic inflammation,34 cases(28.33%)with low-grade squamous intraepithelial lesions(LSIL),30 cases(25.00%)with high-grade squamous intraepithelial lesions(HSIL)and 8 cases(6.67%)with cervical cancer(CC).There were significant differences in clinical symptoms,signs,HPV infection,viral load and distribution of HPV genotypes among patients with different pathological types(P<0.05).Conclusion The incidence of HPV infection is high in the 120 patients with cervical lesions,especially the incidence of HPV 6,HPV 16 and HPV 18 genotypes infection is higher.There are differences in clinical symptoms,signs,HPV infection,viral load and distribution of HPV genotypes among patients with different pathological types of cervical lesions.Clinically,targeted prevention measures can be formulated and implemented based on the above factors.

关 键 词：女性 宫颈病变 人乳头状瘤病毒感染 人乳头状瘤病毒基因分型 病理特征 

分 类 号：R711[医药卫生—妇产科学]