空心硫化铜负载原卟啉用于光热-声动力治疗癌细胞  

Hollow copper sulfide loaded protoporphyrin for photothermal⁃sonodynamic therapy of cancer cells

作　　者：耿鹏 向光璨 张文 兰海闯 肖述章 GENG Peng;XIANG Guangcan;ZHANG Wen;LAN Haichuang;XIAO Shuzhang(Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy,China Three Gorges University,Yichang,Hubei 443002,China;Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials,College of Materials and Chemical Engineering,China Three Gorges University,Yichang,Hubei 443002,China;Hubei Three Gorges Laboratory,Yichang,Hubei 443007,China)

机构地区：[1]三峡大学,肿瘤微环境与免疫治疗湖北省重点实验室,宜昌443002 [2]三峡大学材料与化工学院,无机非金属晶态与能源转换材料重点实验室,宜昌443002 [3]湖北三峡实验室,宜昌443007

出　　处：《无机化学学报》2024年第10期1903-1910,共8页Chinese Journal of Inorganic Chemistry

基　　金：肿瘤微环境与免疫治疗湖北省重点实验室开放基金(No.2023KZL037);国家自然科学基金(No.22171163);111项目(No.D20015);湖北省自然科学基金(No.2024AFB059);宜昌市自然科学研究项目(No.A23⁃2⁃025)资助。

摘　　要：制备了空心硫化铜(H⁃Cu_(2-x)S)纳米颗粒,并利用其空腔结构负载声敏剂原卟啉(PpIX)得到多功能复合纳米试剂(PpIX@H⁃Cu_(2-x)S)。H⁃Cu_(2-x)S在近红外光(NIR)照射条件下具有良好的光热转换效果,同时具有大的比表面积(68 m^(2)·g^(-1)),可实现声敏剂PpIX的高效负载。在超声(US)激发条件下(10 min),发现有46.1%的1,3⁃二苯基异苯并呋喃(DPBF)被PpIX@H⁃Cu_(2-x)S产生的活性氧(ROS)氧化。在体外细胞实验中,PpIX@H⁃Cu_(2-x)S显示出良好的生物安全性,在NIR/US激发条件下可以高效地杀死肿瘤细胞。Hollow copper sulfide(H⁃Cu_(2-x)S)nanoparticles were developed and multifunctional nanoagent(PpIX@H⁃Cu_(2-x)S)was obtained by loading sonosensitizers protoporphyrin(PpIX)in their cavity structures.H⁃Cu_(2-x)S had a good photothermal conversion effect under near⁃infrared(NIR)light irradiation conditions and had a large specific sur⁃face area(68 m^(2)·g^(-1)),which could realize efficient loading of sonosensitizers PpIX.Under ultrasonic(US)excitation conditions(10 min),it was found that 46.1%of 1,3⁃diphenylisobenzofuran(DPBF)was oxidized by reactive oxygen species(ROS)produced by PpIX@H⁃Cu_(2-x)S.In vitro cell experiments,PpIX@H⁃Cu_(2-x)S had shown good biosafety and could effectively kill tumor cells under NIR/US excitation conditions.

关 键 词：空心硫化铜 原卟啉 光热治疗 声动力治疗 活性氧 

分 类 号：O165.3[理学—数学]