锰、铋共掺杂铌酸钠压电效应促进细胞增殖及抗菌  

Piezoelectric effect of Mn,Bi co⁃doped sodium niobate for promoting cell proliferation and bacteriostasis

作　　者：王世鹏 解尚谕 梁露娴 王雪红[1] 魏杰[1] 王德强[1] WANG Shipeng;XIE Shangyu;LIANG Luxian;WANG Xuehong;WEI Jie;WANG Deqiang(School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China)

机构地区：[1]华东理工大学材料科学与工程学院,上海200237

出　　处：《无机化学学报》2024年第10期1919-1931,共13页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.32171340)资助。

摘　　要：通过水热法制备了锰、铋共掺杂铌酸钠压电骨修复材料。通过扫描电镜、X射线衍射仪、X射线光电子能谱仪、压电力显微镜、电化学工作站、紫外可见近红外光谱仪、电子顺磁共振波谱仪等对该材料的微观形貌、组成结构、压电性能、声动力性能和类酶活性等进行表征。结果表明,该材料兼具压电性能和类酶活性,超声触发压电响应不仅促进细胞增殖,而且增强声动力和类酶活性,产生活性氧,协同杀死细菌/清除生物膜。A bone repair material of Mn,Bi co⁃doped sodium niobate with piezoelectricity was prepared using the hydrothermal method.The microscopic morphology,composition,piezoelectricity,sonodynamic and enzyme⁃like activity of the material was characterized by scanning electron microscope,X⁃ray diffractometer,X⁃ray photoelec⁃tron spectrometer,piezoelectric force microscope,electrochemical workstation,ultraviolet⁃visible⁃near⁃infrared spectrometer,and electron paramagnetic resonance spectrometer.The results demonstrate that the material possess⁃es both piezoelectric properties and enzyme⁃like activity;the ultrasound⁃triggered piezoelectric effect not only pro⁃motes cell proliferation but also enhances sonodynamic and enzyme⁃like activity,which generates reactive oxygen species for synergistic killing of bacteria/removal of biofilm.

关 键 词：压电效应 声动力 类酶活性 细胞增殖 抗菌 

分 类 号：R318.08[医药卫生—生物医学工程]