Synthesis,crystal structures,and antibacterial activities of two zinc(Ⅱ) complexes bearing 5⁃phenyl⁃1H⁃pyrazole group  

两个含5-苯基-1H-吡唑锌(Ⅱ)配合物的合成、晶体结构及抗菌活性

作　　者：LIU Chao WU Jiang JIN Zhaolei 刘超;吴疆;金赵磊(宿州学院化学化工学院,宿州234000;安徽省自旋电子及纳米材料重点实验室,宿州234000)

机构地区：[1]School of Chemistry and Chemical Engineering,Suzhou University,Suzhou,Anhui 234000,China [2]Anhui Key Laboratory of Spin Electron and Nanomaterials,Suzhou,Anhui 234000,China

出　　处：《无机化学学报》2024年第10期1986-1994,共9页Chinese Journal of Inorganic Chemistry

基　　金：安徽省高校自然科学重点研究项目(No.KJ2020A0737);国家级大学生创新创业训练计划项目(No.202310379009)资助。

摘　　要：A novel compound(H_(2)L)SCN(5⁃methyl⁃3⁃phenyl⁃2H⁃pyrazol⁃1⁃ium thiocyanate)has been obtained by the reaction of thiosemicarbazide with benzoylacetone in ethanol.Two zinccomplexes[Zn(HL)_(2)(NCS)(CH_(3)COO)](1)and[Zn_(2)(L)_(2)(HL)_(2)(NCS)_(2)]_(2)·2CH_(3)OH(2)have been synthesized by the coordination reactions of Zn(OAc)_(2)·2H_(2)O or ZnCl_(2)with(H_(2)L)SCN under reflux conditions.Elemental analyses and single⁃crystal X⁃ray diffraction have con⁃firmed the structures of the synthesized compounds.The(H_(2)L)SCN ligand and complex 1 pertain to the triclinic sys⁃tem with space group P1,while complex 2 belongs to the monoclinic system with space group P2_(1)/n.Additionally,the antibacterial activities of the compounds were evaluated in vitro using the agar diffusion method against the bac⁃terial strains(Candida albicans,Staphylococcus aureus,and Escherichia coli).The results showed that the ligand exhibited relatively good antibacterial activities against the bacteria,and the complexes possessed stronger antibac⁃terial activities against the same bacteria than the free ligand.CCDC:2190252,(H2L)SCN;2190253,1;2190256,2.在甲醇中用氨基硫脲和苯甲酰丙酮反应,合成了一种新颖的化合物(H2L)SCN(5⁃methyl⁃3⁃phenyl⁃2H⁃pyrazol⁃1⁃ium thiocya⁃nate)。在回流条件下,二水醋酸锌或氯化锌与(H_(2)L)SCN发生配位反应,合成了2种锌配合物[Zn(HL)_(2)(NCS)(CH_(3)COO)](1)和[Zn_(2)(L)_(2)(HL)_(2)(NCS)_(2)]_(2)·2CH_(3)OH(2)。合成的化合物的结构均通过元素分析和单晶X射线衍射确认。配体(H2L)SCN和配合物1属于三斜晶系P1空间群,配合物2属于单斜晶系P2_(1)/n空间群。此外,采用琼脂扩散法评价了化合物对白色念珠菌、金黄色葡萄球菌和大肠杆菌菌株的体外抗菌活性。结果表明,配体对这些细菌具有较好的抗菌活性,配合物对同一细菌的抗菌活性比配体更强。

关 键 词：zinccomplex 5⁃phenyl⁃1H⁃pyrazole THIOCYANATE crystal structure BACTERIA 

分 类 号：O614.241[理学—无机化学]