中药干预Th17/Treg平衡治疗溃疡性结肠炎研究进展  

Research Progress in Intervention of Chinese Materia Medica in Th17/Treg Balance in the Treatment of Ulcerative Colitis

作　　者：李开楊 杨梅 黄敬 蔺晓源[3] 刘杰民[4] 唐云 郭震凡 石慧 杨月月 黄财玉 赵琦 LI Kaiyang;YANG Mei;HUANG Jing;LIN Xiaoyuan;LIU Jiemin;TANG Yun;GUO Zhenfan;SHI Hui;YANG Yueyue;HUANG Caiyu;ZHAO Qi(Guizhou University of Traditional Chinese Medicine,Guiyang 550002,China;The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China;The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China;Guizhou Provincial People’s Hospital,Guiyang 550002,China;The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China)

机构地区：[1]贵州中医药大学,贵州贵阳550002 [2]贵州中医药大学第二附属医院,贵州贵阳550001 [3]湖南中医药大学第一附属医院,湖南长沙410007 [4]贵州省人民医院,贵州贵阳550002 [5]贵州中医药大学第一附属医院,贵州贵阳550001

出　　处：《中国中医药信息杂志》2024年第10期191-196,F0003,共7页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(82060850、82160866);贵州农村产业革命石斛专项资金项目(2020年);贵州省高等学校重点实验室(2023年)。

摘　　要：溃疡性结肠炎(UC)病理机制尚不完全清楚,可能是辅助性T细胞17(Th17)/调节性T细胞(Treg)免疫平衡失调及其他多种复杂因素相互作用的结果。大量研究发现,中药经典方剂、经验效方及中药活性成分可通过干预细胞因子、转录因子和信号通路调节Th17/Treg平衡,恢复肠黏膜免疫功能,抑制肠黏膜炎症反应,以修复肠黏膜屏障损伤。本文基于UC研究现状、Th17/Treg平衡及中药治疗,综述Th17/Treg平衡与UC的关系,阐释Th17/Treg平衡在UC发生发展中的关键作用。同时,对近年靶向调节Th17/Treg平衡以治疗UC的中药进行归纳,为UC治疗提供参考。Pathological mechanism of ulcerative colitis(UC)is not fully clear,which may be the result of Th17/Treg immune imbalance and the interaction of multiple complex factors.Numerous studies have found that classical TCM prescriptions,experienced formulas and TCM active components could regulate Th17/Treg balance by intervening in cytokines,transcription factors,and signaling pathways,restore intestinal mucosal immune function,suppress intestinal mucosal inflammatory response,and repair intestinal mucosal barrier damage.Based on the research status of UC,Th17/Treg balance and TCM treatment,this article reviewed the relationship between Th17/Treg balance and UC,and explained the key role of Th17/Treg balance in the occurrence and development of UC.At the same time,the Chinese materia medica targeting to regulate the balance of Th17/Treg in the treatment of UC in recent years was summarized,in order to provide reference for the treatment of UC.

关 键 词：溃疡性结肠炎 Th17/Treg平衡 作用机制 中药 综述 

分 类 号：R259.741[医药卫生—中西医结合]