昼夜节律相关因子在椎间盘退行性变发病机制中作用的研究进展  

Research progress on function of circadian rhythm related factors in the pathogenesis of intervertebral disc degeneration

作　　者：李争光 宰爽嘉 吴火峰 孙华 张永博 陈浏阳 戴睿 张亮 Li Zhengguang;Zai Shuangjia;Wu Huofeng;Sun Hua;Zhang Yongbo;Chen Liuyang;Dai Rui;Zhang Liang(Department of Orthopedics,the Yangzhou Clinical Medical College of Xuzhou Medical University,Yangzhou 221004,China;Department of Orthopedics,Northern Jiangsu People′s Hospital Affiliated to Yangzhou University,Yangzhou 225001,China;Department of Orthopedics,the Yangzhou School of Clinical Medicine of Dalian Medical University,Dalian 116044,China)

机构地区：[1]徐州医科大学扬州临床学院骨科,扬州221004 [2]扬州大学附属苏北人民医院骨科,225001 [3]大连医科大学扬州临床医学院骨科,116044

出　　处：《中华损伤与修复杂志（电子版）》2024年第5期455-459,共5页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：国家自然科学基金面上项目(82172462);江苏省中医药科技发展计划项目(YB2020085);江苏省第六期“333工程”优秀青年人才科研项目(11)。

摘　　要：椎间盘退行性变引发的腰痛已严重影响人们的生活和工作。人类生活作息的变化可影响椎间盘的内在昼夜节律相关因子,进而破坏椎间盘的正常生理活动,加重椎间盘退行性变。本文对昼夜节律相关因子在椎间盘退行性变机制中的影响进行综述,以期为椎间盘退行性变提供新的治疗思路。Low back pain caused by intervertebral disc degeneration seriously affects human life and work.The changes of human life and rest affect the internal circadian rhythm related factors of intervertebral disc,thus affecting the normal physiological activities of intervertebral disc,which may aggravate intervertebral disc degeneration.In this review,the influence of circadian rhythm related factors in the mechanism of intervertebral disc degeneration is reviewed,in order to provide a new treatment idea for intervertebral disc degeneration.

关 键 词：椎间盘退行性变 昼夜节律 自噬 脉冲电磁场 

分 类 号：R68[医药卫生—骨科学]