Enhanced wear resistance,antibacterial performance,and biocompatibility using nanotubes containing nano-Ag and bioceramics in vitro  

作　　者：Qingge Wang Jia Liu Hong Wu Jingbo Liu Yaojia Ren Luxin Liang Xinxin Yan Ian Baker Shifeng Liu V.V.Uglov Chengliang Yang Liqiang Wang 

机构地区：[1]State Key Laboratory of Powder Metallurgy,Central South University,Changsha 410083,China [2]Affiliated Hospital of Youjiang Medical University for Nationalities,Guangxi Key Laboratory for Preclinical and Translational Research on Bone and Joint Degenerative Diseases,Guangxi Zhuang Autonomous Region Engineering Research Center for Biomaterials in Bone and Joint Degenerative Diseases,Guangxi Key Laboratory for Biomedical Material Research,Baise 533000,China [3]Department of Orthopedics,The Second Xiangya Hospital,Central South University,Changsha 410011,China [4]Department of Orthopedics,Renmin Hospital,Wuhan University,Wuhan 430060,China [5]Thayer School of Engineering,Dartmouth College,Hanover,NH 03755-8000,USA [6]School of Metallurgical Engineering,Xi’an University of Architecture and Technology,Xi’an 710055,China [7]Belarusian State University,220030 Minsk,Belarus [8]State Key Laboratory of Metal Matrix Composites,School of Material Science and Engineering,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Bio-Design and Manufacturing》2024年第5期670-686,共17页生物设计与制造（英文）

基　　金：supported by the National Natural Science Foundation of China(Nos.52071346,52111530193,and 52274387);the Natural Science Foundation of Hunan Province for Distinguished Young Scholars(No.2023JJ10075);the Hunan Provincial Natural Science Foundation of China(No.2021JJ30846);the Central South University Research Program of Advanced Interdisciplinary Studies(No.2023QYJC038);the Funding for the Medical Engineering Cross Disciplinary Project at Shanghai Jiao Tong University,and the Fundamental Research Funds for the Central Universities of Central South University(No.2022ZZTS0402);The authors would also thank Sinoma Institute of Materials Research(Guangzhou)Co.,Ltd.for the assistance with the TEM characterization.

摘　　要：A good Ti-based joint implant should prevent stress shielding and achieve good bioactivity and anti-infection performance.To meet these requirements,the low-elastic-modulus alloy—Ti–35Nb–2Ta–3Zr—was used as the substrate,and functional coatings that contained bioceramics and Ag ions were prepared for coating on TiO_(2)nanotubes(diameter:(80±20)nm and(150±40)nm)using anodization,deposition,and spin-coating methods.The effects of the bioceramics(nano-β-tricalcium phosphate,microhydroxyapatite(micro-HA),and meso-CaSiO_(3))and Ag nanoparticles(size:(50±20)nm)on the antibacterial activity and the tribocorrosion,corrosion,and early in vitro osteogenic behaviors of the nanotubes were investigated.The tribocorrosion and corrosion results showed that the wear rate and corrosive rate were highly dependent on the features of the nanotube surface.Micro-HA showed great wear resistance with a wear rate of(1.26±0.06)×10^(−3)mm^(3)/(N·m)due to adhesive and abrasivewear.Meso-CaSiO_(3)showed enhanced cell adhesion,proliferation,and alkaline phosphatase activity.The coatings that contained nano-Ag exhibited good antibacterial activity with an antibacterial rate of≥89.5%against Escherichia coli.These findings indicate that hybrid coatings may have the potential to accelerate osteogenesis.

关 键 词：βTi alloy Surface modification Wear resistance Corrosion resistance Osteogenic behavior Antibacterial activity 

分 类 号：TG178[金属学及工艺—金属表面处理] R318.08[金属学及工艺—金属学]