Light-based 3D printing of stimulus-responsive hydrogels forminiature devices:recent progress and perspective  

作　　者：Chen Xin Neng Xia Li Zhang 

机构地区：[1]Department of Mechanical and Automation Engineering,The Chinese University of Hong Kong,Hong Kong 999077,China [2]Multi-Scale Medical Robotics Center,Hong Kong Science Park,Shatin NT,Hong Kong 999077,China [3]Chow Yuk Ho Technology Center for Innovative Medicine,The Chinese University of Hong Kong,Hong Kong 999077,China [4]Department of Surgery,The Chinese University of Hong Kong,Hong Kong 999077,China [5]CUHK T Stone Robotics Institute,The Chinese University of Hong Kong,Hong Kong 999077,China

出　　处：《Bio-Design and Manufacturing》2024年第5期721-746,共26页生物设计与制造（英文）

基　　金：financially supported by the Research Impact Fund (project no. R4015-21);Research Fellow Scheme (project no. RFS2122-4S03);Strategic Topics Grant (project no. STG1/E-401/23- N) from the Hong Kong Research Grants Council (RGC);the CUHK internal grants;the support from Multi-Scale Medical Robotics Centre (MRC),InnoHK, at the Hong Kong Science Park;the SIAT–CUHK Joint Laboratory of Robotics and Intelligent Systems

摘　　要：Miniature devices comprising stimulus-responsive hydrogels with high environmental adaptability are now considered competitive candidates in the fields of biomedicine,precise sensors,and tunable optics.Reliable and advanced fabricationmethods are critical formaximizing the application capabilities ofminiature devices.Light-based three-dimensional(3D)printing technology offers the advantages of a wide range of applicable materials,high processing accuracy,and strong 3D fabrication capability,which is suitable for the development of miniature devices with various functions.This paper summarizes and highlights the recent advances in light-based 3D-printed miniaturized devices,with a focus on the latest breakthroughs in lightbased fabrication technologies,smart stimulus-responsive hydrogels,and tunable miniature devices for the fields of miniature cargo manipulation,targeted drug and cell delivery,active scaffolds,environmental sensing,and optical imaging.Finally,the challenges in the transition of tunable miniaturized devices from the laboratory to practical engineering applications are presented.Future opportunities that will promote the development of tunable microdevices are elaborated,contributing to their improved understanding of these miniature devices and further realizing their practical applications in various fields.

关 键 词：3D printing Stimulus-responsive hydrogels Miniature devices Shape-morphing 

分 类 号：R318.08[医药卫生—生物医学工程] TP391.73[医药卫生—基础医学] TQ427.26[自动化与计算机技术—计算机应用技术]