基于微生态调控的植物性抑菌养发液的制备及功效评价  

Preparation and efficacy evaluation of plant antibacterial hair⁃nourishing liquids based on microecological regulation

作　　者：贺天儒 佘傲 罗智 彭心悦 梁浩[2] 周延[2] HE TianRu;SHE Ao;LUO Zhi;PENG XinYue;LIANG Hao;ZHOU Yan(School of International Education,Beijing University of Chemical Technology,Beijing 100029,China;College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China)

机构地区：[1]北京化工大学国际教育学院,北京100029 [2]北京化工大学生命科学与技术学院,北京100029

出　　处：《北京化工大学学报（自然科学版）》2024年第5期69-76,共8页Journal of Beijing University of Chemical Technology(Natural Science Edition)

基　　金：国家重点研发计划(2021YFC2101500)。

摘　　要：各类头皮健康问题严重困扰着人们的日常生活,目前市售的头皮护理产品常针对某种单一症状添加药物进行治疗,无法较为全面地改善头皮健康问题伴随的多种症状。此外,头皮上富含多种微生物种群,长时间使用头皮护理产品还会引起头皮表面的微生态失调,导致病症反复发作。为此,提出重构头皮微生态的配方设计思路,以多种天然提取物为主要活性成分制备了植物性抑菌养发液,并较为全面地考察了其养发护发功效。结果显示,在抑菌组分含量为2 mg/mL时,养发液对糠秕马拉色菌的抑制作用较强(抑菌率94.6%),对痤疮丙酸杆菌的抑制作用相对较弱(抑菌率83.1%),对表皮葡萄球菌具有一定的抑制作用(抑菌率82.7%),表明所制备的养发液具有调控头皮微生态的作用。受试者使用养发液7周后,去屑率可达94.2%;使用养发液1个月后,油脂分泌异常症状有所好转,头皮红肿程度减轻,发丝直径明显增大,脱发程度亦有所减轻。Many kinds of scalp health problems seriously trouble people’s daily life.At present,commercially available scalp care products often have specific drugs added to treat a single symptom and cannot comprehensively improve the various symptoms associated with scalp health problems.In addition,the scalp has a rich microbial population,and long-term use of scalp care products can cause microecological disorders on the scalp surface,leading to repeated disease episodes.In view of this,a formulation designed to reconstruct the scalp microecology was proposed.Plant antibacterial hair-nourishing liquids with various natural extracts as the main active compo-nents were prepared,and their hair care effects were investigated.The results showed that when the antibacterial component content was 2 mg/mL,the hair-nourishing liquids had a strong inhibitory effect on Malassezia furfur(inhibition rate of 94.6%),a relatively weak inhibitory effect on Cutibacterium acnes(inhibition rate of 83.1%),and a certain inhibitory effect on Staphylococcus epidermidis(inhibition rate of 82.7%),indicating that the pre-pared hair-nourishing liquids had the effect of regulating scalp microecology.After 7 weeks of using the hair-nour-ishing liquids,the dandruff removal rate of the subjects could reach 94.2%.After 1 month of using the hair-nour-ishing liquids,the symptoms of abnormal oil secretion were improved,the degree of scalp redness and swelling was reduced,the hair diameter was significantly increased,and the degree of hair loss was also reduced.

关 键 词：头皮微生态 养发液 天然提取物 功效评价 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]