Ferroptosis:Iron-mediated cell death linked to disease pathogenesis  

作　　者：Xiangyu Zhang Yingchao Hu Bingwei Wang Shuo Yang 

机构地区：[1]Department of Immunology,State Key Laboratory of Reproductive Medicine,Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Personalized Cancer Medicine,Gusu School,the Affiliated Wuxi People's Hospital of Nanjing Medical University,Wuxi People's Hospital,Wuxi Medical Center,Nanjing Medical University,Nanjing,Jiangsu 211166,China [2]Department of Pharmacology,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210023,China

出　　处：《Journal of Biomedical Research》2024年第5期413-435,共23页生物医学研究杂志（英文版）

基　　金：supported by the National Key Research and Development Program of China(Grant No.2022YFA1303900 to S.Y.);the National Natural Science Foundation of China(Grant Nos.32270921 and 82070567 to S.Y.,and 82204354 to Y.H.);the Open Project of State Key Laboratory of Reproductive Medicine of Nanjing Medical University(Grant No.SKLRM-2021B3 to S.Y.)'the Talent Cultivation Project of"Organized Scientific Research"of Nanjing Medical University(Grant No.NJMURC20220014 to S.Y.);the Natural Science Foundation of Jiangsu Province(Grant No.BK20221352 to B.W.);the Jiangsu Provincial Outstanding Postdoctoral Program(Grant No.2022ZB419 to Y.H.);the Postdoctoral Research Funding Project of Gusu School(Grant No.GSBSHKY202104 to Y.H.);the China Postdoctoral Science Foundation(Grant No.2023T160329 to Y.H.).

摘　　要：Ferroptosis is a pattern of iron-mediated regulatory cell death characterized by oxidative damage.The molecular regulatory mechanisms are related to iron metabolism,lipid peroxidation,and glutathione metabolism.Additionally,some immunological signaling pathways,such as the cyclic GMP-AMP synthase-stimulator of the interferon gene axis,the Janus kinase-signal transducer and activator of transcription 1 axis,and the transforming growth factor beta 1-Smad3 axis,may also participate in the regulation of ferroptosis.Studies have shown that ferroptosis is significantly associated with many diseases such as cancer,neurodegenerative diseases,inflammatory diseases,and autoimmune diseases.Considering the pivotal role of ferroptosis-regulating signaling in the pathogenesis of diverse diseases,the development of ferroptosis inducers or inhibitors may have significant clinical potential for the treatment of aforementioned conditions.

关 键 词：ferroptosis lipid peroxidation molecular regulatory mechanisms ferroptosis-related diseases ferroptosis inducers ferroptosis inhibitors 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学]