Evaluating short-term and long-term liver fibrosis improvement in hepatitis C patients after DAA treatment  

作　　者：Yifan Wang Xinyan Ma Yanzheng Zou Ming Yue Meiling Zhang Rongbin Yu Hongbo Chen Peng Huang 

机构地区：[1]Department of Infectious Disease,Jurong Hospital Affiliated to Jiangsu University,Jurong,Jiangsu 212400,China [2]Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China [3]Department of Infectious Diseases,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China

出　　处：《Journal of Biomedical Research》2024年第5期464-472,I0001,I0002,共11页生物医学研究杂志（英文版）

基　　金：sponsored by the National Natural Science Foundation of China(Grant No.82273691);the Natural Science Foundation of Jiangsu Province(Grant No.BK20190106);the Nanjing Important Science&Technology Specific Projects(Grant No.2021-11005);the National Natural Youth Science Foundation of China(Grant No.81703273);the Priority Academic Program Development of Jiangsu Higher Education Institutions.

摘　　要：Despite achieving a high cure rate with the direct-acting antivirals(DAAs)in hepatitis C treatment,further research is needed to identify additional benefits of the DAA therapy.The current study evaluated liver fibrosis improvement in 848 hepatitis C patients treated with DAAs,who also achieved sustained virologic response.By the fibrosis-4(FIB-4)index,patients were categorized based on their baseline fibrosis levels,and the improvement in fibrosis was analyzed in both short-term(9-26 weeks)and long-term(≥36 weeks)follow-up.The results showed a significant decrease in the FIB-4 index,indicating an improvement in liver fibrosis,in 63.0%and 67.6%of the patients during the short-term and long-term follow-up,respectively.Short-term improvement was associated with factors including ribavirin usage,blood cholinesterase levels,alanine transaminase levels,albumin levels,and the baseline FIB-4 index,while long-term improvement was associated with factors such as aspartate transaminase levels,total protein level,and the baseline FIB-4 index.The current study emphasizes the importance of continuous assessment and post-treatment monitoring of liver fibrosis,which will provide crucial insights for enhancing patient care in hepatitis C management.

关 键 词：chronic hepatitis C sustained virologic response direct-acting antivirals liver fibrosis 

分 类 号：R512.63[医药卫生—内科学]