四川省攀枝花市18~45岁健康女性人乳头瘤病毒感染状况调查  

Human papillomavirus infection in healthy women aged 18‒45 years in Panzhihua of Sichuan Province

作　　者：李华 黄婷[2] 蓝羲[1] 黄小梅[1] LI Hua;HUANG Ting;LAN Xi;HUANG Xiaomei(Panzhihua Center for Disease Control and Prevention,Panzhihua,Sichuan 617000,China;Sichuan Provincial Center for Disease Control and Prevention,Chengdu,Sichuan 610044,China)

机构地区：[1]攀枝花市疾病预防控制中心,四川攀枝花617000 [2]四川省疾病预防控制中心,四川成都610044

出　　处：《上海预防医学》2024年第8期721-725,共5页Shanghai Journal of Preventive Medicine

基　　金：攀枝花市市级指导性科技计划项目(2023ZD-S-38)。

摘　　要：【目的】了解18~45岁健康女性人乳头瘤病毒(HPV)感染情况及可能的影响因素,为预防HPV感染和防治宫颈癌提供科学数据。【方法】将四川省攀枝花市1210名自愿参与检测的健康女性作为研究对象,采用聚合酶链式反应(PCR)‑反向点杂交法进行23种HPV型别检查,分析HPV各亚型感染状况,分析不同年龄、民族、婚姻史、妊娠史、性伴人数及首次性交年龄者的HPV感染情况。【结果】1210名调查者中共检测出HPV阳性267人,感染率为22.07%;不同年龄组、不同民族HPV感染率差异无统计学意义者(均P>0.05),婚姻史中对HPV感染影响较大的为离异/丧偶(53.57%),不同婚姻史者HPV感染率差异有统计学意义(χ^(2)=35.16,P<0.05);有妊娠史的1207名女性中,妊娠5次及以上者的HPV感染率高达30.58%,但不同妊娠次数者HPV感染率差异无统计学意义(χ^(2)=10.07,P=0.07);性伴人数越多,感染HPV的可能越大,性伴人数不同者间HPV感染率差异有统计学意义(P<0.05)。首次性交年龄越小,HPV感染率越高,首次性交年龄不同者的HPV感染率差异有统计学意义(χ^(2)=17.37,P<0.05)。【结论】攀枝花市健康女性HPV感染以单一型别感染为主,流行的亚型以HPV52、81、53等型别为主,流行病学调查发现婚姻史、性伴人数多、首次性交年龄小为HPV感染的影响因素,提示固定性伴和稳定婚姻关系可减少HPV感染的可能。[Objective]To determine the human papillomavirus(HPV)infection status and possible influencing factors among healthy women aged 18‒45 years,and to provide a scientific evidence for the prevention of HPV infection and cervical cancer.[Methods]A total of 23 HPV types were examined by PCR-reverse dot blot hybridization in 1210 healthy women who voluntarily participated in the study.Infection status of each HPV genotype and possible factors associated with the infection were determined,including age,ethnicity,marital history,pregnancy history,number of sexual partners,and age at first sexual intercourse.[Results]A total of 1210 healthy women were examined,of which 267 tested positive for HPV,with a prevalence of 22.07%.The prevalence did not differ significantly across age groups or ethnicities(all P>0.05).Moreover,the highest prevalence was found in the divorced/widowed participants(53.57%),compared with other marital status(χ^(2)=35.16,P<0.05).Among the 1207 participants with pregnancy history,the highest HPV prevalence was 30.58%in those with five or more pregnancies;however,it did not significantly associated with numbers of pregnancies(χ^(2)=10.07,P=0.07).Number of sexual partners showed a significantly positive association with HPV infection(P<0.05).In addition,earlier age at first sexual intercourse was significantly associated with HPV infection(χ^(2)=17.37,P<0.05).[Conclusion]Healthy women in Panzhihua City were mainly infected with a single HPV type,and the dominant types were HPV 52,81,and 53.Marital history status,higher number of sexual partners,and younger age at first sexual intercourse were influencing factors associated with HPV infection.It suggested that regular sexual partners and stable marital relationship may reduce the risk of HPV infection.

关 键 词：人乳头瘤病毒 婚姻史 性交年龄 性伴人数 HPV感染 

分 类 号：R183[医药卫生—流行病学]