共结晶技术拆分对映异构体实例  

Examples of Enantiomer Resolution by Co-crystallization Technique

作　　者：应会荣 蒋成君 YING Huirong;JIANG Chengjun(Zhejiang Hisoar Pharmaceutical Co.,Ltd.,Taizhou,Zhejiang 318000;School of Biological and Chemical Engineering,Zhejiang University of Science and Technology,Hangzhou 310023)

机构地区：[1]浙江海翔药业股份有限公司,浙江台州318000 [2]浙江科技大学生物与化学工程学院,杭州310023

出　　处：《化工生产与技术》2024年第4期19-22,I0003,共5页Chemical Production and Technology

摘　　要：手性外消旋体拆分是制备单一对映体的最高效、便捷的途径,而结晶拆分是实现手性单一对映体分离最为重要且广泛应用的技术。综述了对映体选择性共晶拆分拉米夫定、巴氯芬、乙拉西坦和布洛芬的实例,这种选择性是共晶体中氢键的高度定向性质导致的,是成盐结晶拆分的有益补充。该技术仍处于发展阶段,设计共晶的手性拆分工艺仍具有不少挑战。Chiral resolution of racemate is the most efficient and convenient way to prepare single enantiomers,and crystal resolution is the most important and widely used technology to achieve chiral single enantiomer separation.The research progress of enantioselective cocrystallization resolution of lamivudine,baclofen,eracetam and ibuprofen is reviewed.This selectivity is caused by the highly oriented nature of hydrogen bonds in cocrystal,and is a useful supplement for salt crystallization resolution.The technology is still in the development stage,and there are still many challenges in designing chiral resolution processes for cocrystallization.

关 键 词：对映体 选择性 共晶 拆分 

分 类 号：TQ463[化学工程—制药化工]