拉曼光谱技术在脑胶质瘤检测中的应用研究  

Application of Raman spectroscopy in the detection of brain glioma

作　　者：葛梅兰 王与烨[1,2] 李海滨 徐德刚[1,2] 姚建铨[1,2] GE Mei-lan;WANG Yu-ye;LI Hai-bin;XU De-gang;YAO Jian-quan(School of Precision Instruments and Optoelectronics Engineering,Tianjin University,Tianjin 300072,China;Key Laboratory of Optoelectronic Information Technology,Ministry of Education,Tianjin University,Tianjin 300072,China)

机构地区：[1]天津大学精密仪器与光电子工程学院,天津300072 [2]天津大学光电信息技术教育部重点实验室,天津300072

出　　处：《中国光学（中英文）》2024年第5期995-1013,共19页Chinese Optics

基　　金：国家自然科学基金(No.62175182,No.U22A20353,No.62275193,No.U22A20123)。

摘　　要：脑胶质瘤是一种常见的颅内原发性肿瘤,具有治愈率低、复发率高等特点。脑胶质瘤边界的精准识别是减少患者术后复发、改善愈后状况的重要前提。因此,发展快速、高灵敏度、无标记的脑胶质瘤诊断方法具有重要的临床意义。拉曼光谱技术作为一种指纹谱,能够在分子水平上反映物质的化学和结构信息,已经在脑胶质瘤的定性定位识别中表现出巨大的应用前景。本文首先介绍了不同种类的拉曼光谱技术,其次梳理了拉曼光谱技术在脑胶质瘤中的研究现状,最后对拉曼光谱技术在脑胶质瘤检测中的未来发展进行展望。Brain glioma is a common type of brain tumor with a low cure rate and a high recurrence rate.Precise identification of tumor boundaries is an important prerequisite for reducing recurrence and improving prognosis.Developing a rapid,high-sensitivity and label-free diagnostic method is of crucial clinical significance regarding glioma.Raman spectroscopy can reflect substance’s chemical and structural information at the molecular level due to its fingerprint characteristics.It has already shown excellent prospects for the location and identification of glioma.Firstly,we introduce the different types of Raman spectroscopy technologies in this paper.Secondly,the research status of glioma diagnosis based on Raman spectroscopy is reviewed.Finally,the future development of glioma diagnosis through Raman spectroscopy is prospected.

关 键 词：拉曼光谱 脑胶质瘤 检测 识别 

分 类 号：TN29[电子电信—物理电子学]