蒽环类药物心脏毒性的中西药防治策略  

Chinese and Western Medicine Control Strategies for Anthracycline Cardiotoxicity

作　　者：钱俊 张淑敏 仇慧鑫 刘思彤 邓雁如[1] 舒乐新[1] QIAN Jun;ZHANG Shumin;QIU Huixin;LIU Sitong;DENG Yanru;SHU Lexin(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学中药学院,天津301617

出　　处：《世界科学技术-中医药现代化》2024年第7期1706-1714,共9页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会青年科学基金项目(82204799):基于“益气养阴”关联代谢通量的参麦方改善蒽环类化疗药物心脏毒性的作用机制研究,负责人:舒乐新。

摘　　要：蒽环类药物的心脏毒性对其临床使用造成极大限制,为探究蒽环类心脏毒性的规律及中西药防治策略,本文通过文献检索对蒽环类药物心脏毒性的发生机制和防治药物进行了归纳总结,其机制可分氧化应激、炎性反应、心肌细胞自噬以及DNA损伤4大类。防治药物西药以右丙亚胺、ACEI、ARB等为主,中药可分为单药、经方及中成药。在此基础上,对联合用药防治心脏毒性进行了讨论,介绍了西药、中药及中西药联合应用的理论依据及研究现状,结果表明其具有良好的可行性和安全性,可为临床上蒽环类化疗药物心脏毒性的防治策略研究提供参考。Cardiac toxicity of anthracycline greatly limit its clinical use,to explore the rule of anthracycline cardiotoxicity and prevention and control strategies of Chinese and western medicine,this paper through the literature search mechanism and drugs is summarized,the mechanism can be divided into oxidative stress,inflammatory reaction,myocardial cell autophagy and DNA damage four categories,the prevention and treatment of western medicine to dc prosamine,ACEI,ARB is given priority to,Chinese medicine can be divided into single medicine,by prescription and proprietary Chinese medicine.On this basis,the combination drug is discussed to prevent cardiotoxicity,and the theoretical basis and research status of the combined application of western medicine,traditional Chinese medicine and Chinese and western medicine are introduced.The results show that it has good feasibility and safety,and can provide reference for the clinical treatment strategy of anthracycline chemotherapy drugs.

关 键 词：蒽环类药物 心脏毒性 防治策略 西药 中药 联合用药 

分 类 号：R972[医药卫生—药品]