保肾通络方对糖尿病肾脏病气阴两虚兼血瘀证的临床疗效观察  

Clinical Research of BaoShenTongLuo on Diabetic Kidney Disease with Qi Yin Deficiency and Blood Stasis

作　　者：崔方强 孟元[1] 王悦芬[1] 蔡朕[1] 江心灿 赵文景[1] CUI Fangqiang;MENG Yuan;WANG Yuefen;CAI Zhen;JIANG Xincan;ZHAO Wenjing(Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)

机构地区：[1]首都医科大学附属北京中医医院,北京100010

出　　处：《世界科学技术-中医药现代化》2024年第7期1840-1846,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会青年项目(81703989):糖肾宁调控Wnt/β-catenin通路减轻糖尿病肾病足细胞EMT作用机制研究,负责人:崔方强;北京市属医院科研培育计划(PZ2019013):保肾通络方干预足细胞上皮-间充质转分化治疗2型糖尿病肾脏病的临床研究,负责人:孟元;首都医科大学科研培育基金(自然类)(PYZ22163):基于PERK-elF2α-ATF4-CHOP通路介导足细胞内质网稳态失衡探讨保肾通络方防治DKD机制研究,负责人:崔方强。

摘　　要：目的观察保肾通络方对于糖尿病肾脏病辨证属气阴两虚兼血瘀证患者的尿蛋白定量、肾功能及其血清炎症因子水平的影响。方法将纳入的80例糖尿病肾脏病(Diabetic kidney disease,DKD)患者随机分组,对照组给予基础治疗,而治疗组在基础治疗的同时加服保肾通络方,12周后检测两组患者24 h尿蛋白、尿白蛋白肌酐比、血清肌酐、血清尿素氮,检测血清炎症因子指标MCP-1、TGF-β1、CRP、IL-6、TNF-α,同时比较两组患者中医证候积分水平。结果治疗组总有效率明显高于对照组(P<0.05),经治疗后的治疗组中医证候积分低于对照组(P<0.01),治疗组在降低DKD患者24 h尿蛋白、尿白蛋白肌酐比、血清肌酐、血清尿素氮水平方面优于对照组(P<0.01),治疗组在降低DKD患者血清炎症因子MCP-1、TGF-β1、CRP、IL-6、TNF-a水平方面优于对照组(P<0.01)。结论保肾通络方可以降低DKD患者蛋白尿、保护肾功能,同时可以降低血清炎症因子水平。Objective To observe the effect of BaoShenTongLuo(BSTL)Decoction on diabetic kidney disease and serum inflammatory factors of DKD.Methods A total of 80 DKD patients were collected from patients of Beijing Hospital of Traditional Chinese Medicine.The patients were then randomly divided into control group and treatment group.Patients in control group were received with basic treatment.Patients in treatment group were received with BSTL decoction along with basic treatment.The treatments were lasted for 3 months.Scr,BUN,UACR,24 h proteinuria,MCP-1,TGF-β1,CRP,IL-6 and TNF-a were detected.Clinical symptom scores of patients in two groups were calculated.Results The total effective rate of treatment group was higher than that in the control group(P<0.05).The scores of TCM symptoms were lower in the treatment group than those in the control group after treatment(P<0.01).Compared with control group,24 h proteinuria,UACR,Scr and BUN was significantly decreased in treatment group after the treatment(P<0.01).After the treatment,the level of MCP-1,TGF-β1,CRP,IL-6 and TNF-αwere significantly decreased in treatment group compared with control group(P<0.01).Conclusion BSTL can significantly decrease proteinuria and improved renal function in DKD.More importantly,BSTL can significantly decrease serum inflammatory factors of DKD.

关 键 词：糖尿病肾脏病 保肾通络方 气阴两虚兼血瘀 炎症因子 临床研究 

分 类 号：R285.6[医药卫生—中药学]