益智化学成分及药理作用研究进展  

Research Progress on Chemical Constituents of Alpinia oxyphylla and its Pharmacological Activities

作　　者：李海波[1] 周汨 董洁 王振中[1] 曹亮[1] 姚新生[2] 于洋[2] 肖伟[1] LI Haibo;ZHOU Mi;DONG Jie;WANG Zhenzhong;CAO Liang;YAO Xinsheng;YU Yang;XIAO Wei(National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture,Jiangsu Kanion Pharmaceutical Co.Ltd.,Lianyungang 222001,China;Institute of Traditional Chinese Medicine and Natural Products,Jinan University,Guangzhou 510632,China)

机构地区：[1]中药制药过程控制与智能制造技术全国重点实验室、江苏康缘药业股份有限公司,连云港222001 [2]暨南大学中药及天然药物研究所,广州510632

出　　处：《世界科学技术-中医药现代化》2024年第7期1870-1887,共18页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：2021年国家中医药管理局岐黄学者支持项目(国中医药人教函〔2022〕6号),负责人:肖伟;江苏省院士工作站(BM2023118),负责人:田金洲。

摘　　要：益智作为药食两用的常用中药,具有暖肾固精缩尿、温脾止泻摄唾的功效,主治肾虚脾寒所致疾病。益智化学成分丰富,主要含有挥发油194个、萜类121个(其中倍半萜111个)、二苯基庚烷类19个、黄酮类10个、碱基与核苷类10个、甾体类4个、糖苷类8个以及小分子有机酸类成分13个,其具有抗AD/PD、抗肿瘤、抗炎、抗氧化等广泛的药理作用。本文就益智的化学成分及药理作用进行综述,以期为其进一步开发和合理应用提供参考。As a commonly used traditional Chinese medicine,Alpinia oxyphylla is widely used as both medicine and edible resources.A.oxyphylla has the effects of warming the kidney,consolidating essence,contracting urine,warming the spleen,stopping diarrhea and absorbing saliva,which mainly treated diseases caused by kidney deficiency and spleen cold.A.oxyphylla is rich in chemical components,mainly including 194 volatile oil,121 terpenoids(including 111 sesquiterpenoids),19 diphenylheptanes,ten flavonoids,ten bases and nucleosides,four steroids,eight glycosides and 13 organic acids.It has a wide range of pharmacological effects such as anti-AD/PD,anti-tumor,anti-inflammatory,antioxidant,etc.This article reviews the chemical components and pharmacological effects of A.oxyphylla,in order to provide reference for its further development and rational application.

关 键 词：益智 化学成分 倍半萜类 二苯基庚烷类 药理作用 

分 类 号：R284.1[医药卫生—中药学]