可降解生物材料应用于修复感染性骨缺损的研究进展  

Research progress of degradable biomaterials in the repair of infectious bone defects

作　　者：梁枭 吴锦秋[2] 袁凌伟[2] 唐兆鹏[2] 哈达 Liang Xiao;Wu Jinqiu;Yuan Lingwei;Tang Zhaopeng;Ha Da(Graduate School of Gansu University of Traditional Chinese Medicine,Lanzhou Gansu,730000;Department of Sports Medicine,Gansu Hospital of Traditional Chinese Medicine,Lanzhou Gansu,730000,China)

机构地区：[1]甘肃中医药大学研究生院,甘肃兰州730000 [2]甘肃省中医院运动医学科,甘肃兰州730000

出　　处：《生物骨科材料与临床研究》2024年第5期71-76,共6页Orthopaedic Biomechanics Materials and Clinical Study

基　　金：兰州市科技计划项目(2022-3-32)。

摘　　要：与不可降解生物材料相比,可降解生物材料在严重骨缺损的修复中发挥着越来越重要的作用,受到研究者的广泛关注。在骨缺损的治疗中,由可降解生物材料制成的支架可以为新骨组织生长提供爬行的桥梁,并为细胞和生长因子发挥作用提供平台,这些细胞和生长因子最终将在体内降解吸收并被新生骨组织替代。现阶段研究较多的可降解生物材料主要有6种,包括聚乳酸-羟基乙酸共聚物(PLGA)、聚己内酯(PCL)、聚乳酸(PLA)、聚乙醇酸(PGA)、β-磷酸三钙(β-TCP)、羟基磷灰石(HA)。这是一类无毒、具有良好生物相容性和血液相容性的可降解生物材料。本文就可降解生物材料修复感染性骨缺损的研究进展作一系统综述。Compared to non-degradable biomaterials,degradable biomaterials play an increasingly important role in the repair of severe bone defects and have received extensive attention from researchers.In the treatment of bone defects,scaffolds made of degradable biomaterials can provide a crawling bridge for new bone tissue growth and a platform for cells and growth factors to function,which will eventually be degraded and absorbed in the body and replaced by new bone tissue.At present,there are 6 types of degradable biomaterials that are more studied,including polylactic acid-glycolic acid copolymer(PLGA),polycaprolactone(PCL),polylactic acid(PLA),polyglycolic acid(PGA),β-tricalcium phosphate(β-TCP),hydroxyapatite(HA).They are a class of non-toxic,biocompatible and hemocompatible degradable biomaterials.This article reviews the research progress of degradable biomaterials in the repair of infectious bone defects.

关 键 词：骨髓炎 可降解生物材料 感染性骨缺损 复合支架 

分 类 号：R318.08[医药卫生—生物医学工程]