Thermal and Magnetic Dual-Responsive Catheter-Assisted Shape Memory Microrobots for Multistage Vascular Embolization  

作　　者：Qianbi Peng Shu Wang Jianguo Han Chenyang Huang Hengyuan Yu Dong Li Ming Qiu Si Cheng Chong Wu Mingxue Cai Shixiong Fu Binghan Chen Xinyu Wu Shiwei Du Tiantian Xu 

机构地区：[1]Guangdong Provincial Key Lab of Robotics and Intelligent Systems,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China [2]University of Chinese Academy of Sciences,Beijing,China [3]Department of Neurosurgery,South China Hospital,Medical School,Shenzhen University.Shenzhen,China [4]The Key Laboratory of Biomedical Imaging Science and System,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China.

出　　处：《Research》2024年第3期529-543,共15页研究（英文）

基　　金：the National Key Research and Development Project under Grant 2023YFB4705300;in part by the National Natural Science Foundation of China under Grant U22A2064;in part by the Youth Innovation Promotion Association of CAS;in part by the Shenzhen Science and Technology Program under Grant JCYJ20220818101611025;in part by the Guangdong Basic and Applied Basic Research Foundation(2022B1515120010);and in part by SIAT-CUHK Joint Laboratory of Robotics and Intelligent Systems.

摘　　要：Catheters navigating through complex vessels,such as sharp turns or multiple U-turns,remain challenging for vascular embolization.Here,we propose a novel multistage vascular embolization strategy for hard-to-reach vessels that releases untethered swimming shape-memory magnetic microrobots(SMMs)from the prior catheter to the vessel bifurcation.SMMs,made of organo-gel with magnetic particles,ensure biocompatibility,radiopacity,thrombosis,and fast thermal and magnetic responses.An SMM is initially a linear shape with a 0.5-mm diameter at 20°C inserted in a catheter.It transforms into a predetermined helix within 2 s at 38°C blood temperature after being pushed out of the catheter into the blood.SMMs enable agile swimming in confined and tortuous vessels and can swim upstream using helical propulsion with rotating magnetic fields.Moreover,we validated this multistage vascular embolization in living rabbits,completing 100-cm travel and renal artery embolization in 2 min.After 4 weeks,the SMMs maintained the embolic position,and the kidney volume decreased by 36%.

关 键 词：TURNS maintained TRAVEL 

分 类 号：TP242[自动化与计算机技术—检测技术与自动化装置]