Neddylation Regulation of Immune Responses  

作　　者：Hongmei Mao Xin Lin Yi Sun 

机构地区：[1]Cancer Institute(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational Medicine,Zhejiang University School of Medicine,Hangzhou 310029,China [2]Institute for Immunology,School of Medicine,Tsinghua University,Beijing 100084,China [3]Changping Laboratory,Beijing 102206,China [4]Cancer Center of Zhejiang University,Hangzhou 310029,China [5]Zhejiang Provincial Clinical Research Center for Cancer,Hangzhou,Zhejiang Province,China [6]Key Laboratory of Molecular Biology in Medical Sciences,Hangzhou,Zhejiang Province,China [7]Research Center for Life Science and Human Health,Binjiang Institute of Zhejiang University,Hangzhou 310053,China.

出　　处：《Research》2024年第3期545-559,共15页研究（英文）

基　　金：the funds from National Natural Science Foundation of China(92253203 and U22A20317)to Y.S.;the Zhejiang Provincial Natural Science Foundation of China(LD22H300003)to Y.S.;the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2022R01002)to Y.S.;a grant from Research Center for Life Science and Human Health,Binjiang Institute of Zhejiang University(ZY202205SMKY007)to Y.S.

摘　　要：Neddylation plays a vital role in post-translational modification, intricately shaping the regulation of diverse biological processes, including those related to cellular immune responses. In fact, neddylation exerts control over both innate and adaptive immune systems via various mechanisms. Specifically, neddylation influences the function and survival of innate immune cells, activation of pattern recognition receptors and GMP-AMP synthase–stimulator of interferon genes pathways, as well as the release of various cytokines in innate immune reactions. Moreover, neddylation also governs the function and survival of antigen-presenting cells, which are crucial for initiating adaptive immune reactions. In addition, neddylation regulates T cell activation, proliferation, differentiation, survival, and their effector functions, thereby ensuring an appropriate adaptive immune response. In this review, we summarize the most recent findings in these aspects and delve into the connection between dysregulated neddylation events and immunological disorders, especially inflammatory diseases. Lastly, we propose future directions and potential treatments for these diseases by targeting neddylation.

关 键 词：ACTIVATION thereby initiating 

分 类 号：Q75[生物学—分子生物学]