Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction  

作　　者：Yuanlin Cai Ya Lv Liangzhen Shu Zhichao Jin Yonggui Robin Chi Tingting Li 

机构地区：[1]National Key Laboratory of Green Pesticide,Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education,Guizhou University,Guiyang 550025,China [2]School of Chemistry,Chemical Engineering,and Biotechnology,Nanyang Technological University,Singapore 637371,Singapore.

出　　处：《Research》2024年第3期715-721,共7页研究（英文）

基　　金：the National Key Research and Development Program of China(2022YFD1700300);the National Natural Science Foundation of China(22071036);the Program of Introducing Talents of Discipline to Universities of China(111 Program,D20023)at Guizhou University;Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules,Department of Education,Guizhou Province[Qianjiaohe KY(2020)004];the Guizhou Province First-Class Disciplines Project[(Yiliu Xueke Jianshe Xiangmu)-GNYL(2017)008];Guizhou University(China);Singapore National Research Foundation under its NRF Investigatorship(NRF-NRFI2016-06)and Competitive Research Program(NRF-CRP22-2019-0002);Ministry of Education,Singapore,under its MOE AcRF Tier 1 Award(RG7/20,RG70/21),MOE AcRF Tier 2(MOE2019-T2-2-117),and MOE AcRF Tier 3 Award(MOE2018-T3-1-003);a Chair Professorship Grant;and Nanyang Technological University.

摘　　要：An approach utilizing N-heterocyclic carbene for nitrile formation and desymmetrization reaction is developed. The process involves kinetic resolution, with the axially chiral aryl monoaldehydes obtained in moderate yields with excellent optical purities. These axially chiral aryl monoaldehydes can be conveniently transformed into functionalized molecules, showing great potential as catalysts in organic chemistry.

关 键 词：chemistry ALDEHYDES CHIRAL 

分 类 号：O62[理学—有机化学]