环状肉芽肿:共病与治疗  

Granuloma Annulare: Comorbidities and Treatment

作　　者：卢仪 孙青[1] LU Yi;SUN Qing(Department of Dermatology,Qilu Hospital of Shandong University,Jinan 250012,China)

机构地区：[1]山东大学齐鲁医院皮肤科,山东济南250012

出　　处：《中国皮肤性病学杂志》2024年第10期1063-1067,共5页The Chinese Journal of Dermatovenereology

摘　　要：环状肉芽肿是一种炎症性、非感染性肉芽肿性皮肤病。近年研究发现,环状肉芽肿可合并多种共病,包括心血管代谢性疾病、特应性疾病、恶性肿瘤、自身免疫性疾病、精神心理疾病等。环状肉芽肿具有自限性,部分患者无需治疗,而泛发型环状肉芽肿治疗较为困难,缺乏循证医学证据。目前一线治疗为外用或皮损内注射糖皮质激素。生物制剂和小分子药物或可成为环状肉芽肿治疗的新选择。本文重点对环状肉芽肿的共病及机制、治疗现状及新进展进行阐述。Granuloma annulare(GA)is a inflammatory,non-infectious granulomatous skin disorder.Recent studies have found that GA can be associated with cardiometabolic diseases,atopic diseases,malignancy,autoimmune diseases and psychiatric comorbidities.GA is potentially self-limited,and treatment is not always necessary.Management of generalized GA is challenging and is further complicated by the paucity of evidence-based therapies.Topical and intralesional corticosteroids are first-line treatments for GA.Biogics and small molecular drugs are promising new therapeutic options in recalcitrant GA.This article reviews the updated information of granuloma annulare in term of comorbidities and treatment.

关 键 词：环状肉芽肿 共病 治疗 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]