婴幼儿花斑糠疹马拉色菌菌种及致病因素分析  

Analysis of Distribution of Malassezia Species and Pathogenic Factor in Pityriasis Versicolor in Infants

作　　者：江情 金云 樊心怡 徐蕊 罗云鹏 李智华[1] 石路怀 高仰敏 JIANG Qing;JIN Yun;FAN Xinyi;XU Rui;LUO Yunpeng;LI Zhihua;SHI Luhuai;GAO Yangmin(Dermatology Hospital of Jiangxi Province,Jiangxi Provincial Clinical Research Center for Skin Diseases,Candidate Branch of National Clinical Research Center for Skin Diseases,Dermatology Institute of Jiangxi Province,The Affiliated Dermatology Hospital of Nanchang University,Nanchang 330000,China)

机构地区：[1]江西省皮肤病专科医院,江西省皮肤病临床医学研究中心,国家皮肤与免疫疾病临床医学研究中心分中心建设单位,江西省皮肤病研究所,南昌大学附属皮肤病医院,江西南昌330000

出　　处：《中国皮肤性病学杂志》2024年第10期1098-1101,共4页The Chinese Journal of Dermatovenereology

基　　金：江西省卫生健康委员会科技计划项目(202211452);南昌市科技局医疗卫生科技支撑项目(2022-KJZC-026)。

摘　　要：目的了解婴幼儿花斑糠疹患者马拉色菌的菌种分布并进行致病因素分析,以期为婴幼儿花斑糠疹的诊断提供依据。方法招募本院门诊就诊的≤2周岁婴幼儿花斑糠疹患者83例及部分患儿母亲。取患儿皮损鳞屑及部分患儿母亲胸前皮脂屑接种于Leeming和Notman培养基中培养,通过PCR技术和基因测序方法进行马拉色菌菌种鉴定,并对其致病因素进行分析。结果共分离培养出9种马拉色菌,显示患儿花斑糠疹主要致病菌为糠秕马拉色菌(79.59%),其次为钝形马拉色菌和Malassezia japonica。该结果与母亲标本菌种一致率为81.25%,其中糠秕马拉色菌为主要携带菌,一致率为88.89%。结论婴幼儿花斑糠疹主要致病菌为糠秕马拉色菌,病原菌来源可能与母亲携带菌菌种有关。Objective To investigate the species distribution of Malassezia in infants and young children with pityriasis versicolor and analyze the pathogenic factors,aiming to provide a basis for the diagnosis of pityriasis versicolor in this population.Methods A total of 83 infants and young children aged≤2 years diagnosed with pityriasis versicolor who presented at our outpatient clinic,along with some of their mothers,were recruited for this study.Skin scales from the lesions of the affected children and sebum scales from the chest region of some of their mothers were collected and inoculated onto Leeming and Notman media for cultivation.Identification of Malassezia species was performed using PCR technology and gene sequencing methods,and analyzed the pathogenic factors.Results Nine species of Malassezia were isolated.The main pathogen of pityriasis versicolor in infants was Malassezia furfur(79.59%),followed by Malassezia obtuse and Malassezia japonica.The consistency rate of the isolated species between infants and their mothers was 81.25%,among which Malassezia furfur was the main fungal colonization and the consistency was 88.89%.Conclusion The Malassezia furfur is main pathogen in infantile pityriasis versicolor,and the source of the pathogen may be associated with the fungal colonization of mother.

关 键 词：婴幼儿 花斑糠疹 马拉色菌 菌种鉴定 致病因素 

分 类 号：R756.9[医药卫生—皮肤病学与性病学]