短链脂肪酸与免疫细胞治疗寻常性银屑病研究进展  

Research Progress of Short-Chain Fatty Acids and Immune Cells in the Treatment of Psoriasis Vulgaris

作　　者：邱桂荣[1,2] 李晓健 严张仁[1,2] 陈施宇 黄东北[2] 蓝宏荣 程仕萍[1,2] 吴允波[1,2] QIU Guirong;LI Xiaojian;YAN Zhangren;CHEN Shiyu;HUANG Dongbei;LAN Hongrong;CHENG Shiping;WU Yunbo(Jiangxi University of Chinese Medicine,Nanchang 330004,China;Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330006,China)

机构地区：[1]江西中医药大学,江西南昌330004 [2]江西中医药大学附属医院,江西南昌330006

出　　处：《中国皮肤性病学杂志》2024年第10期1162-1167,共6页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金青年科学基金项目(82205038);江西中医药大学科技创新团队(CXTD22009)。

摘　　要：银屑病是一种常见的慢性皮肤疾病,严重影响患者生活质量,其发病机制复杂。肠道微生物与皮肤健康存在关联,短链脂肪酸(SCFAs)是肠道微生物的代谢产物,对宿主免疫和炎症具有调节作用。近年来,越来越多研究揭示了它们对免疫细胞如T细胞、中性粒细胞、树突状细胞和巨噬细胞的活性产生调节作用。本文对SCFAs参与银屑病发病机制和相关的治疗学的研究进展进行了总结。Psoriasis vulgaris is a common chronic disease that significantly impairs the quality of life of patients,and the pathogenesis is complex.There is an association between gut microbiota and skin health,and short-chain fatty acids(SCFAs)are metabolic products of gut microbiota that regulate host immunity and inflammation.In recent years,an increasing number of studies have revealed their regulatory effects on the activity of immune cells such as T cells,neutrophils,dendritic cells and macrophages.This review summarizes the research progress of SCFAs in the pathogenesis and treatment of psoriasis vulgaris.

关 键 词：短链脂肪酸 免疫细胞 寻常性银屑病 研究进展 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]