单细胞测序技术在特应性皮炎细胞亚群分类中的研究进展  

Research Progress of Single-Cell Sequencing in Cell Subsets of Atopic Dermatitis

作　　者：王志敏 秦成 王芳 张红梅 赵永东 杨雪松 叶建州 WANG Zhimin;QIN Cheng;WANG Fang;ZHANG Hongmei;ZHAO Yongdong;YANG Xuesong;YE Jianzhou(First School of Clinic Medicine,Yunnan University of Traditional Chinese Medicine,Kunming 650500,China;School of Pharmacy,Yunnan Minzu University,Kunming 650031,China;Baoshan Higher College of Traditional Chinese Medicine,Baoshan 678013,China;Department of Dermatology,First Affiliated Hospital of Yunnan Traditional Chinese Medicine University,Kunming 650021,China)

机构地区：[1]云南中医药大学第一临床医学院,云南昆明650500 [2]云南民族大学药学院,云南昆明650031 [3]保山中医药高等专科学院,云南保山678013 [4]云南中医药大学第一附属医院云南省中医医院皮肤科,云南昆明650021

出　　处：《中国皮肤性病学杂志》2024年第10期1174-1180,共7页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金项目(82260940);云南省中医(皮肤病)临床医学中心。

摘　　要：单细胞测序技术是生物学领域一项前沿技术,从单个细胞的基因组、转录组、表观遗传学以及蛋白质组获得疾病发展过程中的细胞异质性和表型转变的详细信息。特应性皮炎的单细胞测序研究能成为基础研究的奠基与补充,通过分析特应性皮炎不同细胞的基因表达状态,获取其中的可变剪切和特异转录本,从而发现新的细胞类型,更深层次的从细胞生物学水平探究特应性皮炎的发病机制,促进特应性皮炎的基础研究及其新治疗策略的探寻。本文对单细胞测序在特应性皮炎研究中的进展予以综述。Single-cell sequencing is a cutting-edge technology in the field of biology,used to obtain detailed information about cellular heterogeneity and phenotypic transformations during disease development.In the study of atopic dermatitis(AD),single-cell sequencing serves as a foundational and complementary tool for basic research.Analyzing the gene expression status of different cells in AD allows for the identification of variable splicing and specific transcripts.Furthermore,this approach aids in discovering new cell types and facilitates a deeper exploration of the cellular-level pathogenesis of AD.This paper reviews the progress of single-cell sequencing in AD,aiming to promote basic research and explore new drugs for AD.

关 键 词：单细胞测序 特应性皮炎 细胞异质性 免疫 治疗策略 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]