基于心与小肠相表里探讨脑肠轴与阿尔茨海默病  

Discussion the Intestinal Axis and Alzheimer’s Disease Based on the Theory of Heart Being Connected with Small Intestine

作　　者：耿赫利 王蕾[2] GENG Heli;WANG Lei(The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250013,China;Department of Neurology,The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250001,China)

机构地区：[1]山东中医药大学第一临床医学院,山东济南250013 [2]山东中医药大学第二附属医院神经内科,山东济南250001

出　　处：《光明中医》2024年第18期3800-3803,共4页GUANGMING JOURNAL OF CHINESE MEDICINE

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是一种起病隐匿、进展缓慢、进行性加重的神经退行性病变。大量研究表明,肠道菌群可通过脑肠轴调控中枢神经系统,从而参与AD的发生发展。中医经典理论“心与小肠相表里”认为无论是在生理、病理还是经络方面,心与小肠都紧密相关。此文通过阐述“心与小肠相表里”与脑肠轴的相关性,探讨肠道菌群与AD的关系,以期为防治AD探索新思路,并为从脾论治AD提供一定的理论支撑。Alzheimer's disease(AD)is a neurodegenerative disease that has an insidious onset,progresses slowly,and worsens.A large number of studies have shown that the intestinal flora can regulate the central nervous system through the brain-gut axis,thereby participating in the occurrence and development of AD.The classical theory of traditional Chinese medicine“heart being connected with small intestine”believes that whether in physiology,pathology or meridians,the heart and small intestine are closely related.This paper discussed the relationship between intestinal flora and AD by elaborating the correlation between the heart and small intestine and the brain-gut axis,in order to explore new ideas for the prevention and treatment of AD,which provides a certain theoretical support for the treatment of AD from the spleen.

关 键 词：痴呆 阿尔茨海默病 心与小肠相表里 脑肠轴 肠道菌群 

分 类 号：R277.7[医药卫生—中医学]